Female reproductive factors, menopausal hormone use, and Parkinson's disease

Movement Disorders : Official Journal of the Movement Disorder Society
Rui LiuHonglei Chen

Abstract

The objective of this study was to examine the associations of reproductive factors and exogenous hormone use with risk of Parkinson's disease (PD) among postmenopausal women. The study comprised 119,166 postmenopausal women aged 50 to 71 years in the NIH-AARP Diet and Health Study, who completed a baseline questionnaire in 1995-1996 and a follow-up survey in 2004-2006. A total of 410 self-reported PD diagnoses were identified between 1995 and 2006. Multivariate odds ratios (ORs) and 95% confidence intervals (CIs) were derived from logistic regression models. PD risk was not significantly associated with female reproductive factors including age at menarche, age at first live birth, parity, and age at menopause. For example, compared with women with natural menopause at age 50 to 54 years, the ORs were 1.18, (95% CI, 0.78-1.79) for women with natural menopause aged <45, 1.19 (95% CI, 0.88-1.61) for those aged 45 to 49, and 1.33 (95% CI, 0.91-1.93) for those aged 55 or older. We found that oral contraceptive use for ≥10 years (vs. never used) was associated with lower PD risk (OR, 0.59; 95% CI, 0.38-0.92), but shorter use showed no association. Use of menopausal hormone therapy showed inconsistent results. Compared with non-horm...Continue Reading

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Citations

Sep 29, 2015·Journal of Movement Disorders·Jae Jung LeeYoung H Sohn
May 3, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Connie Marras, Rachel Saunders-Pullman
Jun 5, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Samuel M Goldman, Caroline M Tanner
Sep 27, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Jessica I LundinHarvey Checkoway
Jan 5, 2020·Nature Reviews. Neurology·Sara MeoniElena Moro
Mar 24, 2018·Brain and Behavior·Bjørg Johanne Warø, Jan O Aasly
Aug 9, 2020·European Journal of Epidemiology·Jung Eun YooHye Soon Park
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Jan 6, 2017·Journal of Neurology·Marina PicilloMaria Teresa Pellecchia
Aug 1, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Jason K RussellPaul A Newhouse
Dec 19, 2019·Journal of Neuroinflammation·Wenyuan GuoPingyi Xu
Jan 16, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Carmen M AvramAmie L Hiller
Jul 29, 2020·Neurología : publicación oficial de la Sociedad Española de Neurología·R García-RamosJ C Martínez Castrillo
Mar 17, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Marianne CanonicoAlexis Elbaz
Aug 25, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Cynthia D J KustersBeate R Ritz

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