Female reproductive function and sexually dimorphic prolactin secretion in rats with lesions in the medial preoptic-anterior hypothalamic continuum

Neuroendocrinology
M Jakubowski, J Terkel

Abstract

The role played by the medial preoptic area-anterior hypothalamus (MPOA-AH) in the regulation of reproductive function of the female rat was examined in the first part of the present study. Extensive bilateral lesions placed in different locations of the MPOA-AH continuum resulted in three different patterns of vaginal smears. Lesions located most rostrally and dorsally, sparing the suprachiasmatic nuclei (SCN), resulted in series of successive pseudopregnancies. Lesions located more caudally and ventrally, still sparing the SCN, eventuated in regular oestrus cycles with only occasional pseudopregnancies. MPOA-AH lesions encroaching upon the SCN were associated with persistent vaginal cornification. MPOA-AH-lesioned females exhibiting repeated pseudopregnancies were capable of mating, conceiving, and giving birth. Parturition in these females was uniformly delayed by 1 day and was associated with a variable incidence of stillbirth, cannibalism of newborn, or incomplete placentophagy. As a rule, MPOA-lesioned mothers did not retrieve pups but they did show crouching behaviour and some of them even secreted milk. Thus, while the MPOA subserves in the regulation of oestrous cyclicity and maternal behaviour, it appears to play no e...Continue Reading

Citations

Nov 1, 1988·Brain Research. Developmental Brain Research·R E WatsonG E Hoffman
May 12, 1997·Journal of the Autonomic Nervous System·R B FóscoloC C Coimbra
Oct 26, 2002·Brain Research. Molecular Brain Research·Phyllis E Mann, Robert S Bridges
Dec 3, 2014·Frontiers in Neuroendocrinology·Claudia P CoomansJohanna H Meijer
Dec 3, 2016·Journal of Mammary Gland Biology and Neoplasia·Riva Dill, Ameae M Walker

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