Female reproductive tract has low concentration of SARS-CoV2 receptors.

BioRxiv : the Preprint Server for Biology
Jyoti GoadAleksandar Rajkovic

Abstract

There has been significant concern regarding fertility and reproductive outcomes during the SARS-CoV2 pandemic. Recent data suggests a high concentration of SARS-Cov2 receptors, ACE2 or TMPRSS2 , in nasal epithelium and cornea, which explains person-to-person transmission. We investigated the prevalence of SARS-CoV2 receptors among reproductive tissues by exploring the single-cell sequencing datasets from uterus, myometrium, ovary, fallopian tube, and breast epithelium. We did not detect significant expression of either ACE2 or TMPRSS2 in the normal human myometrium, uterus, ovaries, fallopian tube, or breast. Furthermore, none of the cell types in the female reproductive organs we investigated, showed the co-expression of ACE2 with proteases, TMPRSS2 , Cathepsin B ( CTSB ), and Cathepsin L ( CTSL ) known to facilitate the entry of SARS2-CoV2 into the host cell. These results suggest that myometrium, uterus, ovaries, fallopian tube, and breast are unlikely to be susceptible to infection by SARS-CoV2. Our findings suggest that COVID-19 is unlikely to contribute to pregnancy-related adverse outcomes such as preterm birth, transmission of COVID-19 through breast milk, oogenesis and female fertility.

Citations

Jan 15, 2021·Clinical Microbiology Reviews·Aleksandra SynowiecKrzysztof Pyrc
Feb 17, 2021·Environmental Science and Pollution Research International·Amr El-SayedMohamed Kamel
Apr 9, 2021·HIV/AIDS : Research and Palliative Care·Nicholas EvansSharilyn Almodovar
May 6, 2021·Amino Acids·Pawan Kumar RaghavDinesh Kumar

Datasets Mentioned

BETA
GSE113197

Methods Mentioned

BETA
single-cell sequencing
single cell sequencing
hysterectomy
chip
Hi-Seq
RNA-seq

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