PMID: 9526608Apr 4, 1998Paper

Female reproductive tract immunity in bovine trichomoniasis

American Journal of Reproductive Immunology : AJRI
L B CorbeilR H BonDurant

Abstract

Mechanisms of protective immunity in the female reproductive tract are poorly understood. For sexually transmitted diseases, bovine trichomoniasis is a useful model because it resembles human trichomoniasis to some extent, and antibodies play an important role in protection against these extracellular parasites. Protective efficacy was compared in animals with genital responses of predominantly immunoglobulin G (IgG) or predominantly IgA antibodies to a purified surface antigen of Tritrichomonas foetus. Immunization of mice by various routes with immunoaffinity-purified T. foetus surface antigen (TF1.17) or killed cells was used to define the best routes and antigen combinations to give predominantly IgG or IgA antibodies to TF1.17 antigens in genital secretions. Cattle were then immunized either subcutaneously (SC) two times with TF1.17 antigen and once SC with killed T. foetus or twice SC with TF1.17 antigen and once intravaginally with killed T. foetus. All immunizations were in Quil A adjuvant. Controls were not immunized. Animals were challenged intravaginally with 10(6) T. foetus 3 weeks after the third immunization. Vaginal mucus was collected weekly for culture and antibody assays. Serum was collected weekly, and uterin...Continue Reading

References

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Citations

Jun 16, 2005·The Veterinary Clinics of North America. Food Animal Practice·Robert H Bondurant
Mar 17, 2004·Veterinary Parasitology·Eduardo Rubén CoboCarlos Manuel Campero
Jul 11, 2001·Veterinary Parasitology·E R CoboC M Campero
May 18, 2000·Microbes and Infection·R S Felleisen
Nov 1, 2001·Clinical and Diagnostic Laboratory Immunology·J M VoyichD E Burgess
Jun 21, 2013·Sexually Transmitted Infections·F D Bastida-CorcueraL B Corbeil
Dec 4, 2003·Reproductive Biology and Endocrinology : RB&E·Lynette B CorbeilRobert H BonDurant
Oct 2, 2015·Tropical Animal Health and Production·Aspinas ChapwanyaPete Charles Irons
May 3, 2008·Veterinary Parasitology·Lynette B CorbeilRobert H Bondurant
Oct 4, 2006·Experimental Parasitology·Melanie R Rutkowski, Allen G Harmsen
Apr 9, 2011·Journal of Reproductive Immunology·Eduardo R CoboRobert H BonDurant
Jan 1, 2013·Annual Review of Animal Biosciences·David ParraJ Oriol Sunyer
Nov 6, 2008·Veterinary Pathology·D W AgnewR H BonDurant
Nov 7, 2001·The Journal of Parasitology·J M VoyichD E Burgess

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