Female sex hormone receptors in gallbladder cancer

Journal of Gastrointestinal Cancer
Ramanathan Saranga BharathiKusum Joshi

Abstract

Higher incidence of gallbladder cancer among women suggests a role of female sex hormones in its etiopathogenesis. This paper aims to study the estrogen/progesterone receptor (ER/PR) expression in gallbladder cancer and to correlate the receptor expression with the clinicopathological profile of patients to understand its implication. Forty-seven patients of gallbladder cancer were studied. Tumor specimens were subjected to histopathologic examination. ER/PR expression was evaluated using immunohistochemistry (IHC). Receptor expression was correlated with the clinicopathological profile of the patients. Of the 47 patients, 11 (23.4 %) patients expressed sex hormone receptors. Of the receptor-positive patients, ER and PR were expressed simultaneously in eight patients while ER and PR were expressed individually in two and one patients, respectively. Metaplasia (p < 0.009) and dysplasia (p < 0.002) were found significantly more in hormone-positive group. The presence of hormone receptor correlated with early/operable stage of the tumor (p < 0.048). Hormone negativity correlated with inoperable/metastatic stage IVB (p < 0.004). The receptor status did not have any correlation with age, sex, menopausal status, presence/absence of g...Continue Reading

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Citations

May 31, 2019·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Nivetha GanesanIsmail Labgaa
Jun 1, 2020·Annals of Surgical Oncology·Adriana C Gamboa, Shishir K Maithel
Nov 30, 2019·Journal of Cellular and Molecular Medicine·Shuai HuangJian Wang

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