Female-specific effects of the catechol-O-methyl transferase Val158Met gene polymorphism on working memory-related brain function.

Aging
Jialing FanZhanjun Zhang

Abstract

The catechol-O-methyltransferase (COMT) Val158Met polymorphism has been associated with working memory (WM) in many studies, but the results have not been consistent. One plausible explanation is sex-specific effects of this polymorphism as reported in several studies. The current study aimed to explore the sex-specific effects of the COMT Val158Met polymorphism on WM-related brain function in an elderly sample. We found that Val homozygotes outperformed Met allele carriers on the backward digit span subtest for both males and females. The triangular part of the left inferior frontal gyrus and the left inferior temporal gyrus exhibited higher activation in Met allele carriers compared with Val homozygotes during the n-back task, while the background functional connectivity (bFC) between the left angular gyrus (ANG) and the right ANG was enhanced in Val homozygotes as compared to Met allele carriers. Finally, the associations between brain activation, bFC (among various regions), and WM performance were identified only in specific genotype groups of the female participants. These findings provide new insights into the role of COMT Val158Met gene polymorphism in brain function, particularly its female-specific nature.

References

Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·J A GogosM Karayiorgou
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·M F EganD R Weinberger
Feb 13, 2002·Behavior Genetics·J AndoM J Wright
Apr 2, 2002·The American Journal of Psychiatry·Anil K MalhotraDavid Goldman
Apr 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Venkata S MattayDaniel R Weinberger
Oct 3, 2003·Nature Reviews. Neuroscience·Alan Baddeley
Oct 24, 2003·Neuropharmacology·H JiangS L Ho
Jul 10, 2004·Trends in Cognitive Sciences·Terry E Goldberg, Daniel R Weinberger
Sep 24, 2004·Progress in Neurobiology·Jeremy K Seamans, Charles R Yang
Feb 16, 2006·Biological Psychiatry·Elizabeth M TunbridgeDaniel R Weinberger
Mar 3, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Wendy R KatesRobert J Shprintzen
Jul 22, 2006·Neuroscience Letters·Janneke ZinkstokDon Linszen
Aug 4, 2006·NeuroImage·Georg WintererDaniel R Weinberger
Sep 5, 2006·Biological Psychiatry·Alessandro BertolinoTommaso Scarabino
Oct 13, 2006·Neuroscience Letters·Ruth O'HaraJoachim Hallmayer
Dec 6, 2006·Archives of General Psychiatry·Emily M DrabantDaniel R Weinberger
Jan 5, 2007·The American Journal of Psychiatry·Jennifer H BarnettPeter B Jones
Sep 6, 2007·Neuropsychology·William S KremenMichael J Lyons
Sep 7, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Paul J Harrison, Elizabeth M Tunbridge
Jan 24, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·M AguileraL Fañanás
Mar 15, 2008·Biological Psychiatry·Jennifer H BarnettMarcus R Munafò
Sep 18, 2008·The International Journal of Neuropsychopharmacology·Matthew J KemptonSophia Frangou
Oct 30, 2008·Frontiers in Human Neuroscience·Irene E NagelUlman Lindenberger
Feb 20, 2009·Frontiers in Neuroscience·Ulman LindenbergerLars Bäckman
May 7, 2009·Molecular Psychiatry·D MierA Meyer-Lindenberg
Jun 2, 2009·Biological Psychology·Eliza CongdonTurhan Canli
Dec 15, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Paul R A StokesMitul A Mehta
Jun 10, 2011·The New England Journal of Medicine·Ronald C Petersen
Jun 15, 2011·Cerebral Cortex·Samuel V Norman-HaignereNicholas B Turk-Browne
Sep 1, 2011·Behavioural Brain Research·Katherine H KarlsgodtDavid C Glahn
Nov 2, 2013·Science·Nicholas B Turk-Browne
Jan 31, 2014·Journal of the American Geriatrics Society·Xin LiYongyan Wang

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Methods Mentioned

BETA
PCR
genotyping

Software Mentioned

Prime
SPSS
SPM8
DPABI

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