PMID: 9421794Jan 9, 1998Paper

Female steroid hormones regulate production of pro-inflammatory molecules in uterine leukocytes

Journal of Reproductive Immunology
J S HuntB L DeBrot

Abstract

Estrogens and progesterone could be among the environmental signals that govern uterine immune cell synthesis of pro-inflammatory substances. In order to investigate this possibility, we first mapped expression of the inducible nitric oxide synthase (iNOS) and tumor necrosis factor-alpha (TNF-alpha) genes in the leukocytes of cycling and pregnant mouse uteri, then tested the ability of estradiol-17 beta (E2) and progesterone to influence gene expression. Immunohistochemistry, in situ hybridization, and other experimental approaches, revealed that the iNOS and TNF-alpha genes are expressed in mouse uterine mast cells, macrophages and natural killer cells (uNK). Gene expression in each cell type was noted to be dependent upon stage of the cycle or stage of gestation, implying potential relationships with levels of female hormones and state of cell differentiation or activation. Further in vivo and in vitro experiments showed that individual hormones have cell type-specific effects on synthesis of iNOS and TNF-alpha that are exerted at the level of transcription. In uterine mast cells, iNOS and TNF-alpha are promoted by E2 whereas preliminary studies in macrophages suggest that transcription and translation of the two genes are un...Continue Reading

References

Jan 1, 1989·Annual Review of Immunology·B Beutler, A Cerami
Sep 1, 1989·Journal of Reproductive Immunology·J S Hunt
May 1, 1994·Journal of Vascular Research·W C Sessa
Oct 1, 1995·The Journal of Experimental Medicine·E K HaddadM G Baines
Jan 1, 1994·Critical Reviews in Immunology·S A RobertsonT G Wegmann
May 1, 1994·Biology of Reproduction·R M SilverD W Branch
Mar 1, 1993·American Journal of Obstetrics and Gynecology·R Ditzian-KadanoffM Zilberstein
Mar 1, 1994·Biology of Reproduction·J S Hunt
Feb 1, 1994·Annals of Internal Medicine·C J LowensteinS H Snyder
Jun 15, 1993·Microscopy Research and Technique·B A Croy, Y Kiso
Mar 1, 1996·Biology of Reproduction·J S HuntL Miller
Aug 1, 1996·Journal of Reproductive Immunology·J Szekeres-Bartho, T G Wegmann
Nov 1, 1996·Journal of Reproductive Immunology·J S Hunt, S A Robertson
Oct 1, 1996·Cytokine & Growth Factor Reviews·M PasparakisG Kollias
Jan 1, 1996·Reproduction, Fertility, and Development·L A SalamonsenD E Woolley
Apr 1, 1997·Journal of Neurosurgery·M SuzukiK Inada

❮ Previous
Next ❯

Citations

Oct 26, 1999·Journal of Reproductive Immunology·L A Salamonsen, D E Woolley
Apr 15, 2008·Trends in Endocrinology and Metabolism : TEM·L A Salamonsen
Aug 23, 2001·International Immunopharmacology·M G CifoneA Santoni
Mar 31, 1999·American Journal of Reproductive Immunology : AJRI·L MarxJ Dietl
Jul 4, 2001·Clinical Microbiology Reviews·C W RobertsJ Alexander
Dec 3, 2003·Reproductive Biology and Endocrinology : RB&E·Gregory S Lewis
Jul 4, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·S O'LearyD T Armstrong
Aug 22, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·Richard G Lea, Olivier Sandra
Mar 12, 2016·General and Comparative Endocrinology·Rohini R NairKiran Singh
Feb 19, 2008·Animal Reproduction Science·O I Azawi
Sep 11, 2007·Brain Research Reviews·Donald G Stein
Jul 19, 2005·Annals of the New York Academy of Sciences·Donald G Stein
Sep 27, 2003·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Torunn BrulandAre Dalen
Jan 30, 2004·American Journal of Reproductive Immunology : AJRI·Kristijan CupurdijaPeter Sedlmayr
Jul 14, 2006·American Journal of Reproductive Immunology : AJRI·Gregory S Lewis, Meghan C Wulster-Radcliffe
Nov 23, 2010·American Journal of Reproductive Immunology : AJRI·Catherine A Blish, Jared M Baeten
Oct 3, 2006·Annals of Emergency Medicine·David W WrightDonald G Stein
Mar 26, 2005·American Journal of Reproductive Immunology : AJRI·Charles R WiraMargaret A Crane-Godreau
May 15, 2013·General and Comparative Endocrinology·Yasmin Z ChishtiChristopher J Martyniuk
May 23, 2014·Frontiers in Immunology·Anne SchumacherAna Claudia Zenclussen
Aug 2, 2016·Fertility and Sterility·Kassie J Hyde, Danny J Schust
Jul 24, 2004·Animal Reproduction Science·G S Lewis
Jan 30, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Helen M Bramlett, W Dalton Dietrich
Dec 29, 1998·Current Opinion in Obstetrics & Gynecology·Y Iwatani, M Watanabe
Aug 16, 2002·American Journal of Physiology. Heart and Circulatory Physiology·John L MershonKenneth E Clark
Mar 29, 2002·AIDS·Birgit H B van BenthemUNKNOWN European Study on the Natural History of HIV Infection in Women and the Swiss HIV Cohort Study

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.