PMID: 9663922Jul 15, 1998Paper

Female Wistar-Kyoto and SHR/y rats have the same genotype but different patterns of expression of renin and angiotensinogen genes

Journal of Hypertension
A MilstedD L Ely

Abstract

To evaluate whether renin and angiotensinogen gene expression in females from two strains of rats that share the same autosomes and X chromosomes differs. Female SHR/y rats have the parental Wistar-Kyoto rat autosomes and X chromosomes and have no chromosomes of spontaneously hypertensive rat origin; thus they are genetically equivalent to female Wistar-Kyoto rats. Because these genes are regulated by steroid hormones, we investigated the effects of removal of estrogen (ovariectomy) and addition of androgen (testosterone implants) on three groups of female SHR/y rats and the parental rat strain Wistar-Kyoto rat with groups of intact (control) rats, rats subjected to ovariectomy at age 3 weeks, and rats subjected to ovariectomy with a testosterone implant at age 3 weeks. The combination of removing estrogen early in development and supplementing the ovariectomized females with testosterone revealed strain differences in response of blood pressure. Renin and angiotensinogen messenger RNA levels appear to be regulated coordinately within each strain, although actual levels of messenger RNA differ between the strains. Similar patterns of responses of renin and angiotensinogen genes to ovariectomy and ovariectomy plus testosterone s...Continue Reading

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Citations

Oct 18, 2005·European Journal of Pharmacology·Juan R Muñoz-CastañedaIsaac Túnez
Mar 31, 2015·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Lidia LuzhnaOlga Kovalchuk
Jun 1, 2000·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·D ElyA Milsted
Dec 17, 2008·Hypertension·Monte E TurnerAmy Milsted
Feb 9, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·D ElyA Milsted
Oct 26, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·I HernándezL F Carbonell
Nov 25, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Xiaomei GuoGhassan S Kassab

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