FemHab: The effects of bed rest and hypoxia on oxidative stress in healthy females

Journal of Applied Physiology
Tadej DebevecG P Millet

Abstract

Independently, both inactivity and hypoxia augment oxidative stress. This study, part of the FemHab project, investigated the combined effects of bed rest-induced unloading and hypoxic exposure on oxidative stress and antioxidant status. Healthy, eumenorrheic females were randomly assigned to the following three, 10-day experimental interventions: normoxic bed rest (NBR;n=11;PiO2=133mmHg); normobaric hypoxic bed rest (HBR;n=12;PiO2=90mmHg) and ambulatory hypoxic confinement (HAMB;n=8;PiO2=90mmHg). Plasma samples, obtained before (Pre), during (D2,D6), immediately after (Post) and 24-hrs after (Post+1) each intervention, were analyzed for oxidative stress markers [advanced oxidation protein products (AOPP), malondialdehyde (MDA) and nitrotyrosine], antioxidant status [superoxide dismutase (SOD), catalase, ferric-reducing antioxidant power (FRAP), glutathione peroxidase (GPX) and uric acid (UA)], NO metabolism end-products (NOx) and nitrites. Compared to baseline, AOPP increased in NBR and HBR on D2 (+14%;+12%;P<0.05), D6 (+19%;+15%;P<0.05) and Post (+22%;+21%;P<0.05), respectively. MDA increased at Post+1 in NBR (+116%;P<0.01) and D2 in HBR (+114%;P<0.01) and HAMB (+95%;P<0.05). Nitrotyrosine decreased (-45%;P<0.05) and nitrites...Continue Reading

References

Oct 1, 1988·Analytical Biochemistry·L H Johansson, L A Borg
Jan 1, 1984·Methods in Enzymology·L W Oberley, D R Spitz
Jul 1, 1994·Free Radical Biology & Medicine·J P Kehrer, L G Lund
May 1, 1996·Kidney International·V Witko-SarsatB Descamps-Latscha
May 9, 1998·Journal of Applied Physiology·R S MazzeoL G Moore
Nov 16, 2001·Sports Medicine·C K Sen
Feb 28, 2002·Cardiovascular Research·Jacques E Rossouw
Mar 17, 2004·Proceedings of the National Academy of Sciences of the United States of America·Rafael Radi
Apr 27, 2004·The Journal of Physiology·Guoxiang YuanNanduri R Prabhakar
May 28, 2004·Emergency Medicine Clinics of North America·Scott A Gallagher, Peter H Hackett
Feb 5, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Ulrich LaufsGeorg Nickenig
Jun 22, 2006·European Journal of Clinical Nutrition·V PialouxN Fellmann
Aug 5, 2006·Medicine and Science in Sports and Exercise·Michalis G NikolaidisDimitris Kouretas
Feb 10, 2007·Journal of Applied Physiology·Scott K PowersJoseph M McClung
May 8, 2007·Respiratory Physiology & Neurobiology·Agoston DosekZsolt Radak
Jul 31, 2007·European Journal of Applied Physiology·A Pavy-Le TraonJ Vernikos
Apr 10, 2008·European Journal of Clinical Nutrition·V PialouxN Fellmann
Jan 30, 2009·International Journal of Sports Medicine·V PialouxN Fellmann
Apr 3, 2009·European Journal of Applied Physiology·Vincent PialouxNicole Fellmann
May 30, 2009·Journal of Applied Physiology·Luciano Dalla LiberaLuisa Gorza
Jul 21, 2009·Free Radical Biology & Medicine·Aristidis S VeskoukisDimitrios Kouretas
Oct 22, 2010·The Journal of Physiology·Francesco AgostiniGianni Biolo
Dec 21, 2010·Free Radical Biology & Medicine·Scott K PowersMatthew B Hudson
Apr 5, 2011·Antioxidants & Redox Signaling·Scott K PowersDavid S Criswell
Apr 5, 2011·Journal of Science and Medicine in Sport·Rebecca E HassonPatty S Freedson
Sep 29, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Hiroyuki TsutsuiShouji Matsushima
Apr 28, 2012·The Journal of Experimental Biology·Michalis G NikolaidisIoannis S Vrabas
Aug 17, 2012·Medicine and Science in Sports and Exercise·Raphael FaissGrégoire P Millet
Sep 26, 2012·International Journal of Sport Nutrition and Exercise Metabolism·Lindsey E MillerJohn C Quindry
Mar 5, 2013·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Stephan F van Eeden, Don D Sin
Jul 13, 2013·Medicine and Science in Sports and Exercise·Tadej DebevecGrégoire P Millet
Feb 21, 2014·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Tadej DebevecIgor B Mekjavic
Mar 29, 2014·International Journal of Sport Nutrition and Exercise Metabolism·Graham McGinnisJohn Quindry
Jun 25, 2014·Current Drug Targets·Elvira BrunelliDaniela Pellegrino
Jan 15, 2015·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Nikos V MargaritelisMichalis G Nikolaidis
Jan 1, 2013·SpringerPlus·Richard J Bloomer, Sang-Rok Lee
Nov 13, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michelle A KingOrlando Laitano

❮ Previous
Next ❯

Citations

Jun 27, 2017·Scandinavian Journal of Medicine & Science in Sports·C BrinkmannK Brixius
Mar 1, 2017·Frontiers in Physiology·Tadej DebevecVincent Pialoux

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
J B SharmaS Mittal
International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
Selçuk KayaMustafa Demirci
© 2022 Meta ULC. All rights reserved