Feminizing adrenocortical tumors: Literature review

Indian Journal of Endocrinology and Metabolism
Farida ChentliSaid Azzoug

Abstract

Feminizing adrenal tumors (FAT) are extremely rare tumors prevailing in males. Clinical manifestations are gynecomastia and/or other hypogonadism features in adults. They are rarer in pediatric population and their main manifestation is peripheral sexual precocity. In women genital bleeding, uterus hypertrophy, high blood pressure and/or abdomen mass may be the only manifestations. On the biological point, estrogen overproduction with or without increase in other adrenal hormones are the main abnormalities. Radiological examination usually shows the tumor, describes its limits and its eventual metastases. Adrenal and endocrine origins are confirmed by biochemical assessments and histology, but that one is unable to distinguish between benign and malignant tumors, except if metastases are already present. Immunostaining using anti-aromatase antibodies is the only tool that distinguishes FAT from other adrenocortical tumors. Abdominal surgery is the best and the first line treatment. For large tumors (≥10 cm), an open access is preferred to coeliosurgery, but for the small ones, or when the surgeon is experienced, endoscopic surgery seems to give excellent results. Surgery can be preceded by adrenolytic agents such as ortho parap...Continue Reading

Citations

May 6, 2016·Endocrine·Andrea SansoneLuigi Di Luigi
Aug 28, 2018·Clinical Case Reports·Valeria CalcaterraDaniela Larizza
Apr 3, 2020·Pediatrics in Review·Claci A WallsLars M Wagner
Mar 14, 2020·Medicina clínica·Juan Bertholle-GilJoana Nicolau-Ramis
Feb 8, 2022·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Vikrant GosaviTushar Bandgar

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