Femtosecond Laser Mass Spectrometry and High Harmonic Spectroscopy of Xylene Isomers

Scientific Reports
A F AlharbiRavi Bhardwaj

Abstract

Structural isomers, molecules having the same chemical formula but with atoms bonded in different order, are hard to identify using conventional spectroscopy and mass spectrometry. They exhibit virtually indistinguishable mass spectra when ionized by electrons. Laser mass spectrometry based on photoionization of the isomers has emerged as a promising alternative but requires shaped ultrafast laser pulses. Here we use transform limited femtosecond pulses to distinguish the isomers using two methods. First, we probe doubly charged parent ions with circularly polarized light. We show that the yield of doubly charged ortho-xylene decreases while para-xylene increases over a range of laser intensities when the laser polarization is changed from linear to circular. Second, we probe high harmonic generation from randomly oriented isomer molecules subjected to an intense laser field. We show that the yield of high-order harmonics varies with the positioning of the methyl group in xylene isomers (ortho-, para- and meta-) and is due to differences in the strength of tunnel ionization and the overlap between the angular peaks of ionization and photo-recombination.

References

Mar 1, 1994·Physical Review. a·M LewensteinP B Corkum
Sep 27, 1993·Physical Review Letters·P B Corkum
Dec 17, 2004·Nature·J ItataniD M Villeneuve
Jul 13, 2006·The Journal of Physical Chemistry. a·Johanna M Dela CruzMarcos Dantus
Oct 3, 2007·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Gunter UrbaschKarl-Michael Weitzel
Oct 16, 2007·The Journal of Physical Chemistry. B·Chi-Kung NiYuri A Dyakov
Jul 25, 2009·Nature·Olga SmirnovaMisha Yu Ivanov
Dec 28, 2010·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·R Santhakumari, K Ramamurthi
Mar 1, 2004·Biochemistry and Molecular Biology Education : a Bimonthly Publication of the International Union of Biochemistry and Molecular Biology·Erin J Finehout, Kelvin H Lee
Feb 5, 2013·Physical Review Letters·M C H WongV R Bhardwaj
Mar 27, 2013·Annual Review of Analytical Chemistry·Albert T Lebedev
Jun 19, 2013·International Journal of Applied & Basic Medical Research·Naveen ChhabraDeepak Padmanabhan

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Citations

Oct 26, 2021·The Journal of Physical Chemistry. a·Kennosuke HoshinaMasashi Tsuge

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Methods Mentioned

BETA
Infrared

Software Mentioned

Gaussian
ePolyScat

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