PMID: 2495916Apr 1, 1989Paper

Fenfluramine increases insulin action in patients with NIDDM

Diabetes Care
R G PestellJ D Best

Abstract

These studies examined the effect of fenfluramine on insulin action and insulin secretion in healthy subjects and patients with non-insulin-dependent diabetes mellitus (NIDDM). In the first study, a double-blind crossover design was used in healthy subjects to compare the effect of short-term fenfluramine therapy (60 mg orally for 3 days) with placebo. Insulin secretion and whole-body insulin sensitivity (determined by frequently sampled intravenous glucose tolerance tests with analysis by the minimal-model method) were unchanged by fenfluramine. In the second study, involving patients with NIDDM inadequately controlled on submaximal to maximal doses of oral hypoglycemic agents, a double-blind crossover strategy was used to compare baseline studies (conducted after a run-in period) with fenfluramine (60 mg orally) or placebo for 4 wk. There was a significant fall in fasting blood glucose after therapy with fenfluramine compared with the baseline study period (13.0 +/- 1.2 vs. 8.4 +/- 0.89 mM, mean +/- SE, P less than .01) with no significant fall in fasting serum insulin (20 +/- 2 vs. 24 +/- 3 microU/ml) or C-peptide (1.3 +/- 0.2 vs. 1.3 +/- 0.1 nM). During euglycemic-hyperinsulinemic (1 mU.kg-1.min-1) clamp studies there was a...Continue Reading

Citations

Apr 7, 2000·Diabetes/metabolism Research and Reviews·A J Scheen, P J Lefèbvre
Apr 14, 2011·International Journal of Clinical Pharmacy·Star Khoza, Jamie C Barner
Jul 22, 2004·Current Diabetes Reports·Kimberly K Trout, Karen L Teff
Oct 24, 1994·European Journal of Pharmacology·F Picarel-BlanchotB Portha
Jul 1, 1994·Baillière's Clinical Endocrinology and Metabolism·J P Després
Mar 5, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Natalie Rasgon, Lissy Jarvik
Jul 1, 1991·Clinical Endocrinology·R T Jung, P Chong
Mar 1, 1994·European Journal of Clinical Investigation·R AroraG Williams
Jun 1, 1995·Diabetic Medicine : a Journal of the British Diabetic Association·J Rachman, R C Turner
Dec 14, 2006·Clinical Drug Investigation·Jørn RexSimon A Lawton
Jan 16, 2008·European Journal of Clinical Pharmacology·Hieronymus J DerijksAntoine C G Egberts
Dec 24, 2005·Expert Opinion on Drug Safety·Roger S McIntyreSidney H Kennedy
Mar 16, 2001·Expert Opinion on Pharmacotherapy·P J Goodnick, M Hernandez
Feb 28, 2008·Pharmacoepidemiology and Drug Safety·Hieronymus J DerijksAntoine C Egberts
May 1, 2015·Journal of Neuroendocrinology·L K Burke, L K Heisler
Nov 1, 2011·The International Journal of Biochemistry & Cell Biology·Wagner Santos CoelhoMauro Sola-Penna
Dec 25, 2003·Diabetes·Mary Courtney MooreAlan D Cherrington
Feb 28, 2001·Diabetes, Obesity & Metabolism·K V Williams, D E Kelley
Mar 1, 1994·Diabetes Research and Clinical Practice·J ProiettoL C Harrison
Nov 29, 2016·Critical Reviews in Food Science and Nutrition·Giovanna MuscogiuriAnnamaria Colao
Oct 20, 1998·European Journal of Clinical Investigation·A Rissanen
Apr 25, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·C J BaileyR B Jones
Jul 6, 2000·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M PiccininiM T Rinaudo
Apr 23, 1999·Journal of Basic and Clinical Physiology and Pharmacology·J W Kolaczynski, J F Caro
Dec 24, 2018·Obesity Science & Practice·H BaysM Malhotra
Feb 1, 1993·The Medical Journal of Australia·G O StewartP Findlater

❮ Previous
Next ❯

Related Concepts

Related Feeds

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.