PMID: 15332227Aug 28, 2004Paper

Fenofibrate-associated reversible acute allograft dysfunction in 3 renal transplant recipients: biopsy evidence of tubular toxicity

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Carmichael AngelesEdward P Nord

Abstract

Renal transplant recipients are susceptible to hyperlipidemia and the development of atherosclerosis as a consequence of the immunosuppressive agents they require, which include corticosteroids, calcineurin inhibitors, and sirolimus. Fibric acid derivatives and 3-hydroxymethylglutaryl-coenzyme A reductase inhibitors are prescribed commonly to optimize lipid profiles and reduce the risk of cardiovascular events in this type of setting. The authors describe 3 cases of reversible acute renal allograft dysfunction in patients treated with fenofibrate. Serum levels of monitored immunosuppressant agents remained therapeutic throughout the time period. Discontinuation of the fenofibrate resulted in the resolution of renal dysfunction. The pathologic changes to the proximal tubules in all 3 biopsy specimens were in keeping with a toxic rather than an ischemic etiology. Although the control of hyperlipidemia is crucial in the transplant patient population, the authors suggest that caution be exercised and serum creatinine levels be closely monitored in patients started on fibrates.

Citations

Feb 16, 2005·Expert Opinion on Drug Safety·Ali J OlyaeiWilliam M Bennett
Jan 24, 2012·Journal of Clinical Lipidology·Rebecca L AttridgeChristopher R Frei
Mar 14, 2013·European Journal of Clinical Investigation·Michael S KostapanosMoses S Elisaf
Aug 10, 2006·Néphrologie & thérapeutique·Svetlana KarieGilbert Deray
Mar 21, 2007·The American Journal of Cardiology·Michael H DavidsonTerry A Jacobson
Aug 27, 2015·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Juan Antonio Martín-NavarroLuis Pedraza-Cezón
Aug 5, 2017·Korean journal of family medicine·Sungjong KimJungun Lee
Jul 4, 2013·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Rebecca L AttridgeWilliam D Linn
Jul 31, 2009·Current Diabetes Reports·Stéphanie BadiouGeorges Mourad
Aug 12, 2009·Current Atherosclerosis Reports·Domenic A Sica
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Joseph Nogueira, Matthew Weir
Feb 9, 2011·Nature Reviews. Endocrinology·Suneel M Udani, George L Bakris
Feb 20, 2020·Expert Opinion on Drug Safety·Claudio PonticelliAlberto Corsini

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.