Fenofibrate improves renal function by amelioration of NOX-4, IL-18, and p53 expression in an experimental model of diabetic nephropathy

Journal of Cellular Biochemistry
Habib YaribeygiAmirhossein Sahebkar

Abstract

Among several pathological mechanisms involved in diabetic nephropathy, oxidative stress, inflammation, and apoptosis play a prominent role. Fenofibrate, a peroxisome proliferator-activated receptor-α (PPAR-α) agonist, has markedly improved oxidative stress and inflammatory responses, but there is no evidence about its effects on interleukin-18 (IL-18), NADPH oxidase type 4 (NOX-4), and p53 expression in diabetic kidneys. The aim of this study was to evaluate possible effects of fenofibrate on improving the underlying mechanisms of diabetic nephropathy. Male Wistar rats were randomly divided into four groups namely, normal, normal treated, diabetic and diabetic treated (N = 6). Diabetes was induced by a single dose of streptozotocin (40 mg/kg; IV). Treated animals received fenofibrate for 8 weeks daily (80 mg/kg; po). All groups were sacrificed on day 56 and blood, urine, and tissue samples were collected. Serum levels of urea, uric acid, creatinine, and glucose were assessed. Then, serum levels of malondialdehyde (MDA), nitrate, and glutathione (GLT), as well as the activities of catalase (CAT) and superoxide dismutase (SOD) enzymes were measured. The expression level of NOX-4, IL-18, and p53 proteins at both mRNA and protein ...Continue Reading

References

Jan 1, 1984·Methods in Enzymology·H Aebi
Jan 1, 1994·Immunology Today·T M Buttke, P A Sandstrom
Sep 1, 1996·The American Journal of Physiology·W Lieberthal, J S Levine
Aug 6, 2004·Endocrine Reviews·Andrea M VincentEva L Feldman
Dec 24, 2004·Diabetes Care·Jorge L GrossThemis Zelmanovitz
Aug 18, 2005·Kidney International·Bernardo Rodríguez-IturbeNosratola D Vaziri
Sep 19, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Michela ZanettiGabriele Grassi
May 31, 2008·Diabetes·Josephine M ForbesMark E Cooper
Apr 28, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Deepa S De SilvaFlora Sam
Dec 4, 2009·Carcinogenesis·Aaron J SchetterCurtis C Harris
Aug 20, 2010·Cardiovascular Therapeutics·Ahmed A Elmarakby, Jennifer C Sullivan
Oct 12, 2010·PPAR Research·Maryam RakhshandehrooSander Kersten
Nov 6, 2010·Antioxidants & Redox Signaling·Dongping Liu, Yang Xu
Sep 13, 2012·Mediators of Inflammation·Andy K H Lim, Gregory H Tesch
Jan 15, 2013·Vascular Pharmacology·Mandeep Kumar Arora, Umesh Kumar Singh
Feb 11, 2014·Journal of the American Society of Nephrology : JASN·Jay C JhaKarin A Jandeleit-Dahm
Jun 18, 2014·World Journal of Diabetes·Montserrat B Duran-Salgado, Alberto F Rubio-Guerra
Aug 2, 2014·Progress in Lipid Research·Amirhossein SahebkarGerald F Watts
Nov 5, 2014·Physiological Reports·Vicki Thallas-BonkeKarin A M Jandeleit-Dahm
Feb 7, 2015·American Journal of Physiology. Renal Physiology·Yves GorinHanna E Abboud
Jun 6, 2015·Expert Review of Clinical Pharmacology·Amirhossein Sahebkar, Gerald F Watts
Sep 20, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Giuseppe DerosaAmirhossein Sahebkar
Dec 15, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Amirhossein SahebkarUNKNOWN Lipid and Blood Pressure Meta-analysis Collaboration (LBPMC) Group
Apr 18, 2016·Metabolism: Clinical and Experimental·Amirhossein SahebkarJorge Joven
Jun 21, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Amirhossein SahebkarLuisa Costanzo
Jan 18, 2017·Journal of Cellular Physiology·Giuseppe DerosaPamela Maffioli
Feb 6, 2017·BMC Medicine·Amirhossein SahebkarUNKNOWN Lipid and Blood Pressure Meta-analysis Collaboration (LBPMC) Group
Jan 3, 2018·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Luis E Simental-MendíaAmirhossein Sahebkar

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Citations

Mar 10, 2020·Oxidative Medicine and Cellular Longevity·Zheng WangLi Li
Dec 12, 2018·Journal of Cellular Physiology·Habib YaribeygiAmirhossein Sahebkar
Feb 13, 2019·Journal of Cellular Physiology·Habib YaribeygiAmirhossein Sahebkar
Jun 26, 2020·Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences·Fatemeh EmamiMehdi Nematbakhsh
Aug 11, 2020·Oxidative Medicine and Cellular Longevity·Jing GuoWei Jing Liu
Jul 12, 2020·International Journal of Molecular Sciences·Beatriz Castejón-VegaJosé M Alvarez-Suarez
May 16, 2020·Drug Discovery Today·Frederikke E SembachLisbeth N Fink
Dec 10, 2020·Journal of Diabetes Research·Habib YaribeygiAmirhossein Sahebkar
Feb 20, 2021·Frontiers in Immunology·Jin Kyung SeokJoo Young Lee
May 23, 2020·European Journal of Pharmacology·Ankit P Laddha, Yogesh A Kulkarni
Dec 5, 2020·Molecular Aspects of Medicine·Andrew E LibbyMoshe Levi
Oct 13, 2019·Life Sciences·Habib YaribeygiAmirhossein Sahebkar
May 20, 2021·Oxidative Medicine and Cellular Longevity·Habib YaribeygiAmirhossein Sahebkar
Sep 3, 2021·BioMed Research International·Habib YaribeygiAmirhossein Sahebkar

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