Fenofibric acid: in combination therapy in the treatment of mixed dyslipidemia

American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions
Lily P H Yang, Gillian M Keating

Abstract

Fenofibric acid activates peroxisome proliferator-activated receptor alpha to modify fatty acid and lipid metabolism. Fenofibric acid is the first member of the fibric acid derivatives (fibrates) class approved for use as combination therapy with HMG-CoA reductase inhibitors (statins). In three randomized, double-blind, multicenter, phase III trials in adult patients with mixed dyslipidemia, up to 12 weeks' treatment with once-daily fenofibric acid 135 mg plus a low- or moderate-dose statin (atorvastatin 20 or 40 mg, rosuvastatin 10 or 20 mg, or simvastatin 20 or 40 mg) improved high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) levels to a significantly greater extent than statin monotherapy, and improved low-density lipoprotein cholesterol (LDL-C) levels to a significantly greater extent than fenofibric acid monotherapy. In a 52-week, open-label, multicenter, extension study, HDL-C, TG, and LDL-C levels continued to improve, or were maintained, during combination therapy with once-daily fenofibric acid 135 mg plus a moderate-dose statin (atorvastatin 40 mg, rosuvastatin 20 mg, or simvastatin 40 mg). Once-daily fenofibric acid 135 mg plus a statin was generally as well tolerated as monotherapy with fenofibric a...Continue Reading

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Citations

Mar 27, 2019·Journal of Cardiovascular Pharmacology and Therapeutics·Eleni PappaMoses S Elisaf
Oct 25, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Thi Thanh Binh NguyenSeong-Tschool Hong
Feb 29, 2020·Chemical Science·Keith LivingstoneCraig Jamieson
Jun 23, 2015·Clinical & Experimental Ophthalmology·Xavier J Fagan, Elaine W Chong
Sep 11, 2018·The Journal of Clinical Investigation·Anna Bianchi-SmiragliaMikhail A Nikiforov

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