Abstract
Vasoactive compounds are known to modulate gene transcription, including nuclear factor kappa B (NF-kappaB), in renal tissues, but the molecular effects of fenoldopam in this setting are not known. The authors used a rat model of surgical acute ischemic nephropathy to test the hypothesis that fenoldopam attenuates ischemia/reperfusion (I/R)-induced NF-kappaB-mediated inflammation. Prospective, single-blind, randomized, controlled animal study. Academic Department of Anesthesiology laboratory. Twenty-four male Sprague-Dawley rats. Rats were anesthetized by intraperitoneal administration of 50 mg/kg of urethane and randomly allocated into 4 groups (n = 6 each): sham operation, sham operation with infusion of 0.1 microg/kg/min of fenoldopam, unilateral renal ischemia (1 hour, left renal artery cross-clamping) followed by 4 hours of reperfusion, and unilateral renal I/R with fenoldopam infusion. Kidney samples were used to measure NF-kappaB DNA-binding activity with an electrophoretic mobility shift assay. NF-kappaB signaling-dependent gene transcription was assessed with microarray analysis, and validated with reverse transcriptase polymerase chain reaction (RT-PCR). Expression of insulin-like growth factor-1 and nitric oxide synt...Continue Reading
References
Apr 7, 1989·Cell·S T Smale, D Baltimore
Jul 1, 1995·Cleveland Clinic Journal of Medicine·F Cosentino
Feb 17, 1996·Lancet·G Liaño, J Pascual
May 30, 1996·The New England Journal of Medicine·R ThadhaniJ V Bonventre
Mar 1, 1997·Renal Failure·C L EdelsteinR W Schrier
Sep 25, 1998·Cardiovascular Research·U BayraktutanA M Shah
Jun 24, 1999·The Journal of Urology·K K DonnahooD R Meldrum
Sep 24, 1999·Current Opinion in Nephrology and Hypertension·S L Ashworth, B A Molitoris
Oct 3, 1999·Critical Care Medicine·V S MathurR R Luther
Feb 16, 2000·Lancet·H Schiffl
Mar 16, 2000·Drugs·M K Dishart, J A Kellum
Oct 18, 2000·Toxicology in Vitro : an International Journal Published in Association with BIBRA·W J MaasJ J van de Sandt
Oct 25, 2000·Life Sciences·M T LiuJ S Kuo
Jul 14, 2001·Journal of Cardiovascular Pharmacology and Therapeutics·T B GilbertM E Benjamin
Sep 29, 2001·Anaesthesia·M HalpennyG D Shorten
Mar 27, 2002·European Journal of Anaesthesiology·M HalpennyG D Shorten
May 15, 2002·Hormone Research·Silvia González-ParraStenvert L S Drop
Jun 7, 2002·The Journal of Urology·K K MeldrumA L Burnett
Jul 9, 2002·The European Journal of Neuroscience·Yang TangFrank R Sharp
Aug 23, 2002·Journal of the American Society of Nephrology : JASN·Faikah GuelerHermann Haller
Dec 13, 2002·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Alberto MedinaManuel Crespo
Sep 12, 2003·Journal of Cardiothoracic and Vascular Anesthesia·Philippe-Primo CaimmiCarlo Degasperis
Sep 17, 2003·European Journal of Anaesthesiology·C MurrayG D Shorten
Feb 12, 2004·Kidney International·Chang Chun CaoChun Fang Zhu
Feb 14, 2004·Cardiovascular Research·Chuanfu LiDavid L Williams
Mar 18, 2004·Antioxidants & Redox Signaling·John E Baker
Apr 21, 2004·Drug News & Perspectives·Timothy C Nichols
Oct 7, 2004·The Annals of Thoracic Surgery·Marco RanucciMaria Francesca Uslenghi
Citations
Oct 31, 2006·Oncogene·T D Gilmore, M Herscovitch
Feb 12, 2011·Nephron. Experimental Nephrology·Amanda M G VersteilenGeert-Jan Tangelder
Sep 11, 2008·Interactive Cardiovascular and Thoracic Surgery·Zaccaria RicciSergio Picardo
Dec 21, 2013·Cancer Gene Therapy·S AravindanN Aravindan
Mar 19, 2014·Gene·Yan-Wei LiHai-Gen Liu
Mar 12, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·Emanuela EspositoSalvatore Cuzzocrea
Nov 27, 2007·Naunyn-Schmiedeberg's Archives of Pharmacology·Prabal K Chatterjee
May 1, 2013·Expert Opinion on Drug Discovery·Ana B SanzAdrián M Ramos
Mar 1, 2012·Kidney International Supplements
Nov 9, 2010·Mutation Research·Jamunarani VeeraraghavanNatarajan Aravindan
Dec 26, 2015·Critical Care : the Official Journal of the Critical Care Forum·Michael A GilliesMarlies Ostermann
Feb 6, 2008·Journal of Cardiothoracic and Vascular Anesthesia·Giovanni LandoniAlberto Zangrillo
Dec 11, 2007·Journal of Cardiothoracic and Vascular Anesthesia·Andrea A CogliatiPaolo Guelfi
Sep 19, 2006·Acta Anaesthesiologica Scandinavica·N AravindanA D Shaw
Dec 1, 2014·Journal of Anesthesia·Gianni BiancofioreFranco Filipponi
Apr 22, 2015·Journal of Biomedical Science·Sheeja AravindanNatarajan Aravindan
Aug 11, 2012·Life Sciences·Amr A FouadIyad Jresat
Aug 29, 2013·The Journal of Surgical Research·Changbin ChuXin Gou
May 1, 2012·European Journal of Pharmacology·Shin OkuiHaruyasu Ueda
Mar 27, 2018·Nephrology·Silvia CoelhoAntónio Jacinto
Jun 24, 2011·Pancreas·Jamunarani VeeraraghavanNatarajan Aravindan
Aug 26, 2006·Kidney & Blood Pressure Research·Natarajan AravindanAndrew Shaw
May 15, 2007·Renal Failure·Natarajan AravindanAndrew D Shaw
Dec 16, 2016·Oncotarget·Sheeja AravindanNatarajan Aravindan
Feb 27, 2007·Molecular and Cellular Biochemistry·Natarajan AravindanAndrew D Shaw
Mar 4, 2008·The International Journal of Artificial Organs·M SchetzJ A Kellum
Dec 11, 2007·Molecular and Cellular Biochemistry·Natarajan AravindanTerence S Herman
Dec 1, 2012·Anaesthesia and Intensive Care·E M MooreA D Nichol