Fenoterol enantiomers do not possess beneficial therapeutic properties of their racemic mixture in the rat model of post myocardial infarction dilated cardiomyopathy.

Cardiovascular Drugs and Therapy
Ismayil AhmetMark Talan

Abstract

A salutary effect of β(2) adrenergic receptor (AR) agonist, fenoterol has been demonstrated in a rat model of post-myocardial infarction (MI) dilated cardiomyopathy (DCM). Recent reports on single cardiomyocyte experiments suggested that out of two enantiomers, RR and SS, that constitute a racemic mixture of fenoterol, only RR-enantiomer is an active component that might be a promising new drug for treatment of chronic heart failure. The objective of this study was to compare the efficacy of the RR enantiomer of fenoterol with efficacy of racemic fenoterol, and SS, an inactive enantiomer, in whole animal experimental models of DCM. Two weeks after induction of MI by permanent ligation of the anterior descending coronary artery early cardiac remodeling and MI size were assessed via echocardiography and rats were divided into treatment groups. Treatment (placebo, racemic fenoterol, RR- or SS-enantiomers of fenoterol) continued for 6 months while progression of DCM was followed by serial echocardiography. Compared with untreated rats, rats treated with racemic fenoterol demonstrated previously described attenuation of LV remodeling, functional decline and the arrest of the MI expansion during the first 2 months of treatment. On th...Continue Reading

References

Feb 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·W Z ZhuR P Xiao
Jun 28, 2005·Pharmacology & Therapeutics·Ming ZhengRui-Ping Xiao
Oct 5, 2010·Journal of Molecular and Cellular Cardiology·Mark I TalanEdward G Lakatta

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Citations

Sep 24, 2015·Journal of Cardiovascular Translational Research·William J Richardson, Jeffrey W Holmes

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