Fenoxaprop-ethyl affects mouse oocyte quality and the underlying mechanisms

Pest Management Science
Ya-Ting HeQing-Yuan Sun

Abstract

Fenoxaprop-ethyl (FE) is an active ingredient of commercially available herbicide formulations. Its overuse has caused much damage to the environment, livestock breeding, agricultural crops and humans. However, little is known about the effects of FE exposure on female reproductive health and the mechanisms underlying those effects. In this study, we investigated the toxic effects of FE on oocyte quality and their underlying mechanisms in mice fed a diet containing FE. Ovary weight and numbers of oocytes were reduced in FE-treated mice. Moreover, oocyte quality was seriously impaired, as shown by the reduced rate of first polar body extrusion and fertilization ability in vivo. In FE-treated mice, oocytes presented reduced actin expression and abnormal meiotic spindle morphology, which indicate that cytoskeletal integrality is disrupted. Also, FE induced mitochondrial dysfunction, reflected by the accumulation of reactive oxygen species (ROS), apoptosis and autophagy, as revealed by fluorescent staining analysis and real-time polymerase chain reaction (qPCR). Finally, FE led to changes in epigenetic modifications such as histone H3K27me3 and H3K9me2 in oocytes. Our results indicate that FE has adverse effects on oocyte quality a...Continue Reading

References

Aug 5, 2004·Molecular Reproduction and Development·Xing-Shen SunJing-He Tan
Sep 7, 2004·Molecular Reproduction and Development·Catherine M H CombellesDavid F Albertini
Apr 20, 2005·Molecular and Cellular Endocrinology·Nava Dekel
Sep 24, 2005·Nature Cell Biology·Manuel ThéryMichel Bornens
Jan 18, 2006·Reproductive Biomedicine Online·Ashok AgarwalRakesh Sharma
Feb 20, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·Hong-Thuy BuiTakashi Miyano
Mar 29, 2007·Reproduction, Fertility, and Development·Qiang Wang, Qing-Yuan Sun
Jun 2, 2009·International Journal of Toxicology·Ramiro Maravilla-GalvánMiguel Betancourt
Sep 15, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Eduardo CasasMiguel Betancourt
Aug 18, 2010·Genes & Development·Jérôme GovinShelley L Berger
Oct 15, 2011·Current Biology : CB·Christine M Field, Péter Lénárt
Feb 23, 2013·Nature Reviews. Molecular Cell Biology·Rong Li, David F Albertini
Feb 3, 2015·Fertility and Sterility·David KeefeKeri Kalmbach
Mar 18, 2015·Mutagenesis·Jun LiuShao-Chen Sun
May 8, 2015·Current Opinion in Cell Biology·Lai Kuan DionneRytis Prekeris
Jun 26, 2015·Scientific Reports·Xing DuanShao-Chen Sun
Jul 16, 2015·Methods in Cell Biology·Alex McDougallRemi Dumollard
Sep 20, 2015·Toxicology and Applied Pharmacology·Fang-Nong LaiWei Shen
Sep 7, 2017·Science Signaling·Adam HornJyoti K Jaiswal
Feb 9, 2018·Cell Biology International·Marcos Roberto ChiarattiCarolina Habermann Macabelli

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