Fentanyl and heroin contained in seized illicit drugs and overdose-related deaths in British Columbia, Canada: An observational analysis

Drug and Alcohol Dependence
Nicholas BaldwinLaunette Marie Rieb

Abstract

Due to the alarming rise in opioid-related overdose deaths, a public health emergency was declared in British Columbia (BC). In this study, we examined the relationship between illicit fentanyl and heroin found in seized drugs and illicit overdose deaths in BC. An observational cross-sectional survey was conducted using BC data from Health Canada's Drug Analysis Service, which analyzes drug samples seized by law enforcement agencies, and non-intentional illicit overdoses from the BC Coroner's Service, from 2000 to 2016. Initial scatter plots and subsequent multivariate regression analysis were performed to describe the potential relationship between seized illicit fentanyl samples and overdose deaths and to determine if this differed from seized heroin and overdose deaths. Fentanyl samples were analyzed for other drug content. Fentanyl is increasingly being found combined with other opioid and non-opioid illicit drugs. Strong positive relationships were found between the number of seized fentanyl samples and total overdose deaths (R2 = 0.97) as well as between seized fentanyl and fentanyl-detected overdose deaths (R2 = 0.99). A positive association was found between the number of seized heroin samples and total overdose deaths ...Continue Reading

References

Jul 25, 2006·Pharmacoepidemiology and Drug Safety·Leonard J PaulozziYongli Xi
Mar 28, 2008·Journal of Forensic Sciences·J Scott DentonMitra B Kalelkar
Nov 21, 2009·Clinical Psychology Review·Jennifer C VeilleuxAdrienne J Heinz
Feb 24, 2015·The American Journal of Drug and Alcohol Abuse·Stephanie LakeThomas Kerr
Mar 31, 2016·The New England Journal of Medicine·Joshua D LeeCharles P O'Brien
Apr 27, 2016·Journal of Bioethical Inquiry·Ernest DruckerIngrid van Beek
Aug 26, 2016·MMWR. Morbidity and Mortality Weekly Report·R Matthew GladdenPuja Seth
Oct 18, 2016·The International Journal on Drug Policy·Julie LatimerAllison M Salmon
Jan 10, 2017·Drug and Alcohol Dependence·Joji Suzuki, Saria El-Haddad
Feb 16, 2017·The New England Journal of Medicine·Richard G Frank, Harold A Pollack

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Citations

Aug 25, 2018·Expert Review of Clinical Pharmacology·Mina Tadrous
Dec 5, 2018·Addiction·Sarah G MarsDaniel Ciccarone
Dec 19, 2018·The Journal of Bone and Joint Surgery. American Volume·Yuvraj AgrawalBassam A Masri
Jan 25, 2020·Expert Opinion on Drug Metabolism & Toxicology·Rajiv BalyanVidya Chidambaran
Feb 18, 2020·Journal of Analytical Toxicology·Kaitlyn B Palmquist, Madeleine J Swortwood
May 23, 2020·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Kate SmolinaChristian G Schütz
Aug 12, 2020·Nursing Philosophy : an International Journal for Healthcare Professionals·Thomas Foth
Sep 12, 2018·Brain Sciences·Paolo FrisoniMatteo Marti
Jul 24, 2020·BMC Health Services Research·Wayne JonesBenedikt Fischer
Jan 26, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Siqingaowa HanWuliji Hasi
Feb 16, 2021·The International Journal on Drug Policy·Jonathan P Caulkins
Feb 17, 2021·Substance Abuse Treatment, Prevention, and Policy·Benedikt FischerDimitri Daldegan-Bueno
Jun 9, 2019·Journal of Substance Abuse Treatment·Yanjia CaoMarcella H Sorg
Apr 9, 2021·Peptides·Richard J Bodnar
Jul 25, 2021·International Journal of Environmental Research and Public Health·Wayne JonesBenedikt Fischer
Jan 22, 2020·The International Journal on Drug Policy·Mohammad KaramouzianJane A Buxton
Jul 28, 2021·The International Journal on Drug Policy·Jihoon LimDimitra Panagiotoglou
Sep 17, 2021·BMC Public Health·Emily BiggarJane A Buxton
Oct 29, 2020·Journal of Pharmaceutical Policy and Practice·Wayne JonesBenedikt Fischer

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