PMID: 6983314Dec 1, 1982Paper

Fentanyl infusion anesthesia for aortocoronary bypass surgery: plasma levels and hemodynamic response

Anesthesia and Analgesia
J S SpriggeC B Srikant

Abstract

Plasma fentanyl concentrations were measured by radioimmunoassay in patients during aortocoronary bypass surgery and correlated with hemodynamic responses to surgical stimulation. Thirty patients scheduled for aortocoronary bypass surgery were divided into three groups of 10. Patients in group 1 received fentanyl, 30 micrograms/kg, as a loading dose followed by an infusion of 0.3 microgram/kg/min; those in group 2 received 40 micrograms/kg as a loading dose followed by an infusion of 0.4 microgram/kg/min; and those in group 3 received 50 micrograms/kg as the loading dose followed by an infusion of 0.5 microgram/kg/min. The total dose of fentanyl administered to each group up to the time of rewarming on cardiopulmonary bypass was 60 micrograms/kg, 90 micrograms/kg, respectively. Each of the dose regimens produced stable plasma concentrations starting approximately 20 minutes after induction and continuing until the infusion was discontinued. Patients in group 1 had a mean plasma concentration of 10 to 12 ng/ml in the stable period compared with 12 to 14 ng/ml in group 2 and 15 to 18 ng/ml in group 3. Fewer patients in group 3 responded to intubation and surgical stimulation than in the other groups, although the differences betw...Continue Reading

Citations

Jan 1, 1987·European Journal of Clinical Pharmacology·G KorenW D Biggar
Jan 1, 1988·European Journal of Clinical Pharmacology·K KumarG H Beemer
Sep 1, 1991·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·W A MutchR J Hudson
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