Fentanyl or dexmedetomidine combined with desflurane for bariatric surgery

Journal of Clinical Anesthesia
James M FeldRanga C Ananda

Abstract

Because fentanyl has ventilatory depressing effects, alternative methods for analgesia may be beneficial for management of bariatric surgery. We evaluated whether dexmedetomidine infusion could replace fentanyl for facilitation of open gastric bypass surgery. Randomized, single blinded, open label. University teaching hospital. Twenty bariatric patients with an average body mass index of 54 to 61 kg/m2 undergoing surgery for open gastric bypass. Patients were randomized to receive either fentanyl (0.5-microg/kg bolus, 0.5 microg.kg(-1).h(-1), n = 10) or dexmedetomidine (0.5-microg/kg bolus, 0.4 microg.kg(-1).h(-1), n = 10) for intraoperative analgesia. In both groups, end-tidal desflurane was adjusted to maintain the bispectral index at 45 to 50. In the operating room, blood pressure and heart rate were measured at 5-minute intervals. Bispectral index and end-tidal desflurane concentration were measured every hour. During recovery in the postanesthesia care unit, patient-evaluated pain scores and morphine use by patient-controlled analgesia pump were determined. During surgery, desflurane concentrations necessary to maintain the bispectral index at 45 to 50 were decreased, and blood pressure and heart rate were lower with in th...Continue Reading

References

Feb 13, 2001·Journal of Pharmaceutical Sciences·S DuttaT Mant
Jan 5, 2002·Critical Care Clinics·M MazeF Cavaliere
Apr 3, 2003·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·James M FeldWilliam E Hoffman
Jan 24, 2004·Anesthesiology·Barbara KabonAndrea Kurz
Apr 17, 2004·Journal of Clinical Gastroenterology·Andrew Ukleja, Ronald L Stone
May 12, 2004·American Journal of Surgery·Clifford W DeveneyDonald B McConnell

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Citations

Jan 18, 2012·Revista brasileira de anestesiologia·Joana Afonso, Flávio Reis
Dec 23, 2008·Acta Anaesthesiologica Taiwanica : Official Journal of the Taiwan Society of Anesthesiologists·Michael J Sheen, Shung-Tai Ho
Dec 22, 2010·British Journal of Anaesthesia·J Ingrande, H J M Lemmens
Jun 16, 2012·Indian Journal of Anaesthesia·Sukhminder Jit Singh BajwaAparajita Panda
Dec 19, 2013·Saudi Journal of Anaesthesia·Mohamed Ahmed MansourMohammed Geddawy
Oct 10, 2013·Journal of Anaesthesiology, Clinical Pharmacology·Velayudha Sidda ReddyVenkatsiva Jangam
Nov 27, 2014·Journal of Anaesthesiology, Clinical Pharmacology·Uddalak ChattopadhyayHirak Biswas
Sep 16, 2011·Current Medical Research and Opinion·Lauren A McQueen-ShadfarAshraf S Habib
Mar 19, 2013·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Patrick Ziemann-GimmelRobert Marema
Apr 27, 2011·Best Practice & Research. Clinical Anaesthesiology·Roman Schumann
Apr 6, 2007·Research in Veterinary Science·R J Gómez-VillamandosJ M Santisteban
Feb 27, 2007·Journal of Clinical Anesthesia·James FeldRanga C Ananda
Dec 18, 2009·Paediatric Anaesthesia·Vivian Man Ying Yuen
Dec 20, 2008·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Liliana SollazziValter Perilli
Mar 24, 2012·Revista brasileira de anestesiologia·Kemal GulsoyBayazit Dikmen
Oct 25, 2016·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Adele Sandra BudianskyNaveen Eipe
Oct 13, 2016·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·George SkroubisTheodore Alexandrides
Oct 18, 2016·Anesthesia, Essays and Researches·Reshma B MuniyappaPrathima P Thamanna
Feb 15, 2007·The Annals of Pharmacotherapy·Anthony T Gerlach, Joseph F Dasta
Jan 21, 2017·Clinical Pharmacokinetics·Maud A S WeerinkPieter Colin
Mar 7, 2018·The Cochrane Database of Systematic Reviews·Dallas DuncanDuminda N Wijeysundera
Feb 19, 2016·The Cochrane Database of Systematic Reviews·Luise Jessen LundorfAnn Merete Møller
Jul 17, 2014·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·April Miller QuidleyKristi Kuper
May 24, 2008·Anesthesia and Analgesia·Burcu TufanogullariDavid A Provost
Jul 29, 2008·Current Opinion in Anaesthesiology·Dominic S CarolloUsha Ramadhyani
Feb 28, 2019·Expert Opinion on Pharmacotherapy·Rodney A GabrielEngy T Said

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