Fentanyl treatment reduces GABAergic inhibition in the CA1 area of the hippocampus 24 h after acute exposure to the drug

Neuropharmacology
E KouvarasG Kostopoulos

Abstract

The effect of in vivo fentanyl treatment on synaptic transmission was studied in the CA1 area of the rat hippocampus. Animals were treated either with saline or fentanyl (4 x 80 microg/kg, s.c./15 min). Intracellular in vitro recordings were obtained, 24 h after treatment, from CA1 pyramidal neurons. No difference in pyramidal neuron basic membrane properties or postsynaptic membrane excitability was observed between neurons from saline- and fentanyl-treated animals. The peak amplitude of fast (f-) and slow (s-) components of IPSPs elicited in standard ACSF and the peak amplitude and rate of rise of isolated f- and s-IPSPs elicited in the presence of antagonists (CNQX, 10 microM; AP-5, 10 microM; CGP 55845, 1 microM; and bicuculline methochloride, 10 microM), in response to various stimulus intensities, was smaller in fentanyl-treated animals. Conversely, the rising slope of excitatory responses was similar in neurons from saline- and fentanyl-treated animals. Furthermore, in fentanyl-treated animals, lower stimulus strengths were required to elicit subthreshold excitatory responses of the same amplitude suggesting that acute exposure to fentanyl increases susceptibility of pyramidal neurons to presynaptic stimulation. GABA imm...Continue Reading

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Citations

Oct 27, 2011·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Liciane Fernandes MedeirosIraci L S Torres
Oct 2, 2009·Peptides·Richard J Bodnar
Aug 27, 2015·Current Opinion in Anaesthesiology·Ryan GrantJason Gerrard
Nov 9, 2010·Behavioural Brain Research·Liciane Fernandes MedeirosIraci Lucena da Silva Torres
Dec 18, 2014·Brain Structure & Function·Claudia S BarzDiego Contreras
Sep 8, 2019·The Journal of Pharmacology and Experimental Therapeutics·Randy Torralva, Aaron Janowsky

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