Fenton reaction-independent ferroptosis therapy via glutathione and iron redox couple sequentially triggered lipid peroxide generator

Biomaterials
Yu-Jing HeHu-Lin Jiang

Abstract

Ferroptosis, a newfound non-apoptotic cell death pathway, results from the accumulation of iron-dependent lipid peroxide (LPO). Recently, emerging iron-based nanomaterials have been extensively developed to induce Fenton reaction-dependent ferroptosis for cancer therapy. However, insufficient amount of H2O2 and limited acidity of tumor could not satisfy the optimal conditions for Fenton reaction, which extremely limited the efficacy of ferroptosis therapy. Herein, we report a novel glutathione (GSH) and iron redox couple sequentially triggered LPO generator (LPOgener) which can directly supply the Fenton reaction-independent downstream executioner of ferroptosis for cancer therapy. By harnessing GSH-mediated Fe3+ reduction and the well-established iron redox couple-mediated lipid peroxidation, LPOgener was constructed by complete ferric ammonium citrate (FAC) and unsaturated lipids-rich phosphatidylcholine, and formed as FAC loaded liposome. The Fe3+ encapsulated in LPOgener could be efficiently reduced to Fe2+ under high GSH level in tumor cells. Subsequently, the formed iron redox couple could trigger overwhelming lipid peroxidation for Fenton reaction-independent ferroptosis. Superior anticancer therapeutic effect with littl...Continue Reading

Citations

Aug 8, 2020·Frontiers in Cell and Developmental Biology·Lesang ShenJianmin Zhang
Nov 25, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Weidong FeiCaihong Zheng
Sep 3, 2020·International Journal of Pharmaceutics·Wenhao WangChuanbin Wu
Feb 6, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Lei XingHu-Lin Jiang
Feb 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Ruijiang LiuRongzhu Lu
Feb 5, 2021·Signal Transduction and Targeted Therapy·Hong-Fa YanPeng Lei
Jun 30, 2021·Journal of Nanobiotechnology·Jingqi XinFeifei An
Jul 10, 2021·Cancer Investigation·Dongning LiXiaoyan Zhao
Aug 8, 2021·Cancers·Can HuangJuan Iovanna
Sep 11, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Qun GuanYu-Bin Dong
Sep 23, 2021·Cell Biology International·Mingcheng LiuLiancheng Lei
Nov 4, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jiaoyang TaoWeidong Fei

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