Fenvalerate-induced alterations in circulatory thyroid hormones and calcium stores in rat brain

Toxicology Letters
P P KaulR C Srimal

Abstract

Intraperitoneal administration of fenvalerate, a synthetic pyrethroid, in male rats for 45 days in doses of 100 and 200 mg/kg body weight/day induced hyperexcitability, tremors and paralysis. Tremors were observed after 7 days and gradually reached maxima on 45th day. The symptoms were more marked in rats treated with 200 mg/kg body weight/day. Fenvalerate provoked significant elevation of circulatory thyroid hormones, namely tri-iodothyronine (T3) and thyroxine (T4). A significant increase in total calcium as well as protein-bound calcium in whole brain and hypothalamus were recorded. The elevation of circulatory thyroid hormones as well as the active calcium pool could be together responsible for impairment of motor activity by altering various neuronal processes.

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Citations

Sep 4, 2009·Biological Trace Element Research·Belma GirayFiliz Hincal
Oct 20, 1998·Thyroid : Official Journal of the American Thyroid Association·F Brucker-Davis
May 12, 2009·Reproductive Toxicology·John D MeekerRuss Hauser
Feb 17, 2015·Toxicology and Applied Pharmacology·Mandana GhisariEva Cecilie Bonefeld-Jørgensen
May 18, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Xiaohui LiuShuang Hao
May 20, 2014·The Science of the Total Environment·Jie ZhangNobumasa Kato
Jul 28, 2016·Environmental Science & Technology·Susanne M BranderDaniel Schlenk
Mar 3, 2017·Environmental Toxicology·Xia WangZhengwei Fu
Mar 25, 2018·Endocrine Connections·Bilal B MughalBarbara A Demeneix
Jan 18, 2005·Alternatives to Laboratory Animals : ATLA·Irma KakkoHanna Tähti
Jan 11, 2020·Frontiers in Endocrinology·Michelle LeemansJean-Baptiste Fini

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