Abstract
Preliminary evidence suggests that fermentable carbohydrate restriction might ameliorate functional gastrointestinal symptoms [FGS] in inflammatory bowel disease [IBD]. Our aim was to determine whether fermentable carbohydrates exacerbate FGS in IBD using a randomised, double-blinded, placebo-controlled, re-challenge trial. Patients with quiescent IBD and FGS responsive to a low FODMAP diet were allocated to a series of 3-day [d] fermentable carbohydrate challenges in random order [fructan, 12 g/d; galacto-oligosaccharides [GOS] 6 g/d; sorbitol, 6 g/d; and glucose placebo, 12 g/d], each separated by a washout period. Symptoms and stool output were measured daily during the challenges. Thirty-two patients with IBD, fulfilling criteria for irritable bowel syndrome, functional bloating, or functional diarrhoea, were recruited and data were available for 29 patients completing all arms [12 Crohn's disease, 17 ulcerative colitis]. Significantly fewer patients reported adequate relief of FGS on the final day day of the fructan challenge [18/29, 62.1%] compared with glucose [26/29, 89.7%] [p = 0.033]. There was greater severity of pain [1.1 vs 0.5, p = 0.004], bloating [1.3 vs 0.6, p = 0.002], flatulence [1.5 vs 0.7, p = 0.004], and f...Continue Reading
References
Feb 1, 1988·Digestive Diseases and Sciences·J SvedlundG Dotevall
Jul 1, 1995·The British Journal of Nutrition·K E Bach Knudsen, I Hessov
Sep 1, 1996·The American Journal of Clinical Nutrition·C MolisJ P Galmiche
Jan 1, 1997·European Journal of Clinical Nutrition·L EllegårdI Bosaeus
Sep 1, 1999·Alimentary Pharmacology & Therapeutics·M CamilleriA R Northcutt
Dec 10, 1999·The American Journal of Medicine·R C Spiller
Feb 28, 2002·The American Journal of Gastroenterology·Magnus SimrénEinar S Björnsson
Apr 15, 2003·Gut·J KellowA Wagner
Dec 24, 2005·Inflammatory Bowel Diseases·Forough FarrokhyarE Jan Irvine
May 9, 2006·Gastroenterology·Douglas A Drossman
May 9, 2006·Gastroenterology·UNKNOWN Design of Treatment Trials CommitteeSander J O Veldhuyzen van Zanten
May 6, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Susan J ShepherdPeter R Gibson
Jul 2, 2008·The British Journal of Nutrition·Carlett Ramirez-FariasPetra Louis
Jan 7, 2009·Journal of Agricultural and Food Chemistry·Jane G MuirPeter R Gibson
Nov 17, 2009·Gastroenterology·Luca MarcianiRobin C Spiller
Jan 28, 2010·Alimentary Pharmacology & Therapeutics·J S BarrettP R Gibson
Jul 28, 2010·Journal of Gastroenterology and Hepatology·Derrick K OngJane G Muir
Feb 1, 2009·Journal of Crohn's & Colitis·Richard B GearryPeter R Gibson
Dec 24, 2010·European Journal of Clinical Nutrition·S DunnK Whelan
Jan 5, 2011·PloS One·Ted J KaptchukAnthony J Lembo
Jan 26, 2011·Gut·Jane L BenjaminJames O Lindsay
Feb 22, 2012·Inflammatory Bowel Diseases·Geert D'HaensPaul Rutgeerts
Jun 29, 2012·The Journal of Nutrition·Heidi M StaudacherKevin Whelan
Aug 30, 2012·The American Journal of Gastroenterology·Stephen J Halpin, Alexander C Ford
Aug 6, 2013·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·C K YaoJ G Muir
Oct 1, 2013·Gastroenterology·Emma P HalmosJane G Muir
Nov 20, 2013·The American Journal of Gastroenterology·Kathryn MurrayRobin C Spiller
Jan 22, 2014·Nature Reviews. Gastroenterology & Hepatology·Heidi M StaudacherKevin Whelan
Jun 11, 2014·Critical Reviews in Food Science and Nutrition·Leonie VogtPaul De Vos
Jul 2, 2014·Inflammatory Bowel Diseases·Jin-Feng LinBo Jiang
Jan 13, 2015·Frontline Gastroenterology·A DhaliwalR P Arasaradnam
Jun 20, 2015·Journal of Nutritional Science·P RamnaniG R Gibson
Jul 29, 2015·The British Journal of Nutrition·Jelena VulevicGlenn R Gibson
Jul 30, 2015·Journal of Crohn's & Colitis·Jacqueline L AndersonKevin Whelan
Feb 26, 2016·Inflammatory Bowel Diseases·Alexis C PrinceKevin Whelan
May 5, 2016·Gastroenterology·Fermín MearinRobin Spiller
Jun 9, 2016·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·Y A McKenzieUNKNOWN (IBS Dietetic Guideline Review Group on behalf of Gastroenterology Specialist Group of the British Dietetic Association)
Aug 6, 2016·Alimentary Pharmacology & Therapeutics·M R BlakeK Whelan
Oct 18, 2016·Gastroenterology·Giles MajorRobin Spiller
Citations
Jan 13, 2018·Journal of Medicinal Food·Sandra Maria BarbalhoPamela Grazielle Correa de Oliveira
Nov 3, 2017·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C J Tuck, S J Vanner
Aug 11, 2018·American Journal of Physiology. Gastrointestinal and Liver Physiology·Pekka MäättänenPhilip M Sherman
Feb 5, 2019·Journal of Crohn's & Colitis·Savini Britto, Richard Kellermayer
May 28, 2019·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·W Czuber-DochanK Whelan
Jul 11, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Caroline J TuckStephen J Vanner
Nov 11, 2019·Current Treatment Options in Gastroenterology·Andrew T WeberBerkeley N Limketkai
Sep 29, 2019·Gut·Christopher Andrew LambA Barney Hawthorne
Dec 21, 2019·Journal of Pediatric Gastroenterology and Nutrition·Joseph A PicoraroNeal S LeLeiko
Jun 21, 2020·Alimentary Pharmacology & Therapeutics·Peter R GibsonJane G Muir
Jun 20, 2020·Molecular Nutrition & Food Research·Kimberly N Weaver, Hans Herfarth
Jan 10, 2019·Nutrients·Jan de VriesFrédérique Respondek
Jan 31, 2019·Frontiers in Immunology·Kohei SugiharaNobuhiko Kamada
Jan 18, 2020·Nutrients·Massimo BelliniAlessandra Rossi
Aug 11, 2020·World Journal of Gastroenterology : WJG·Dipesh H Vasant, Alexander C Ford
May 21, 2019·The American Journal of Clinical Nutrition·Sophie HielNathalie M Delzenne
Nov 18, 2018·Nutrients·Leda RoncoroniNicoletta Pellegrini
May 1, 2019·Nutrients·Nicole GreenDale Lee
May 11, 2019·Nutrients·Fernando RizzelloPaolo Gionchetti
May 20, 2020·Nutrients·Bartosz MalinowskiMonika Szambelan
May 14, 2019·BioPsychoSocial Medicine·Yohei OkawaHiromi Sanada
Sep 22, 2019·Nutrients·Dorota Mańkowska-WierzbickaMarta Stelmach-Mardas
Apr 3, 2020·Nutrients·Maria Chiara MentellaGiacinto Abele Donato Miggiano
Aug 20, 2019·Medical Hypotheses·Yoshiharu Uno
Oct 5, 2020·The Lancet. Gastroenterology & Hepatology·Keeley M FairbrassAlexander C Ford
Jan 6, 2021·Nutrients·Gabrielle WarkMark Danta
Jan 28, 2021·Journal of Clinical Medicine·Spyros PeppasStefanos Bonovas
Sep 22, 2020·European Journal of Gastroenterology & Hepatology·Benjamin CrooksJimmy K Limdi
Dec 10, 2020·Nutrients·Stefan L PopaDan L Dumitrascu
Feb 11, 2021·International Journal of Molecular Sciences·Davide BanfiAndreina Baj
Oct 24, 2020·Nutrients·Genelle R HealeyKevan Jacobson
Nov 12, 2020·Revista da Associação Médica Brasileira·Regina Márcia Soares CavalcanteNadir do Nascimento Nogueira
Feb 16, 2021·World Journal of Experimental Medicine·Marina Moreira de CastroRaquel Franco Leal
Mar 7, 2021·Nutrients·Ugo CucinottaValeria Dipasquale
Apr 4, 2021·Nutrients·Yan JiangSidhartha R Sinha
Apr 4, 2021·Nutrients·Judith WellensJoão Sabino
Oct 6, 2019·Gastroenterology·Selina R CoxKevin Whelan
May 1, 2021·Nutrients·Lorenzo BertaniFrancesco Costa
Jul 27, 2021·Gastroenterology Clinics of North America·Edith Pérez de ArceEamonn M M Quigley
Jul 4, 2021·Journal of Crohn's & Colitis·Selina R CoxKevin Whelan
Aug 8, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Charlotte R HedinKevin Whelan
Oct 8, 2021·The American Journal of Clinical Nutrition·Elise NordinPer M Hellström