Fermentable fiber ameliorates fermentable protein-induced changes in microbial ecology, but not the mucosal response, in the colon of piglets

The Journal of Nutrition
Robert PieperAndrew G Van Kessel

Abstract

Dietary inclusion of fermentable carbohydrates (fCHO) is reported to reduce large intestinal formation of putatively toxic metabolites derived from fermentable proteins (fCP). However, the influence of diets high in fCP concentration on epithelial response and interaction with fCHO is still unclear. Thirty-two weaned piglets were fed 4 diets in a 2 × 2 factorial design with low fCP/low fCHO [14.5% crude protein (CP)/14.5% total dietary fiber (TDF)]; low fCP/high fCHO (14.8% CP/16.6% TDF); high fCP low fCHO (19.8% CP/14.5% TDF); and high fCP/high fCHO (20.1% CP/18.0% TDF) as dietary treatments. After 21-23 d, pigs were killed and colon digesta and tissue samples analyzed for indices of microbial ecology, tissue expression of genes for cell turnover, cytokines, mucus genes (MUC), and oxidative stress indices. Pig performance was unaffected by diet. fCP increased (P < 0.05) cell counts of clostridia in the Clostridium leptum group and total short and branched chain fatty acids, ammonia, putrescine, histamine, and spermidine concentrations, whereas high fCHO increased (P < 0.05) cell counts of clostridia in the C. leptum and C. coccoides groups, shifted the acetate to propionate ratio toward acetate (P < 0.05), and reduced ammonia ...Continue Reading

References

Aug 3, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Manfred SchwerinPeter Junghans
Dec 14, 2002·FEMS Microbiology Letters·Susan E PrydeHarry J Flint
Apr 1, 2003·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·F AhrensJ R Aschenbach
Apr 6, 2004·Biochemical and Biophysical Research Communications·Christian BarmeyerJörg-Dieter Schulzke
Oct 7, 2005·Clinical Chemistry and Laboratory Medicine : CCLM·Marc A J G FischerGuido R M M Haenen
Sep 8, 2006·Applied and Environmental Microbiology·Sandra Macfarlane, George T Macfarlane
Feb 22, 2007·The Journal of Nutrition·Michael Blaut, Thomas Clavel
Nov 2, 2007·Alimentary Pharmacology & Therapeutics·H M HamerR-J Brummer
Jan 9, 2008·Nature Reviews. Microbiology·Harry J FlintBryan A White
Jan 1, 2009·Journal of Innate Immunity·Poonam DharmaniKris Chadee
Mar 11, 2011·The American Journal of Clinical Nutrition·Wendy R RussellHarry J Flint
Jun 24, 2011·PloS One·Marco A R VinoloRui Curi

❮ Previous
Next ❯

Citations

Jul 3, 2013·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·F StumpffJ R Aschenbach
Jul 6, 2014·Molecular Therapy : the Journal of the American Society of Gene Therapy·Rose A WhelanSusanne Hartmann
Jul 16, 2015·Journal of the Science of Food and Agriculture·Eva WeissRainer Mosenthin
Mar 7, 2015·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·R PieperA Bondzio
Aug 31, 2016·Animal Health Research Reviews·R PieperJ Zentek
Dec 30, 2015·Critical Reviews in Food Science and Nutrition·David C DallasJ Bruce German
Feb 1, 2017·BMC Genomics·Martin BeaumontAnnaïg Lan
Oct 16, 2018·Journal of Animal Science·Michael O WellingtonDaniel A Columbus
Sep 3, 2019·Animal : an International Journal of Animal Bioscience·B HumphreyR Faris
Jul 24, 2018·Journal of Animal Science and Biotechnology·Yuming WangShiyan Qiao
Oct 6, 2020·Frontiers in Cellular and Infection Microbiology·Caterina CarcoNicole C Roy
Jul 11, 2018·Journal of Animal Science and Biotechnology·Chuanjian ZhangWeiyun Zhu
Jan 24, 2019·Nature Reviews. Endocrinology·Emanuel E CanforaEllen E Blaak

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.