Fermentable Sugar Ingestion, Gas Production, and Gastrointestinal and Central Nervous System Symptoms in Patients With Functional Disorders

Gastroenterology
Clive H Wilder-SmithAsbjørn M Drewes

Abstract

Functional gastrointestinal disorders (FGID) are defined by broad phenotypic descriptions and exclusion of recognizable disease. FGIDs cause multi-organ symptoms and abnormal results in a wide range of laboratory tests, indicating broad mechanisms of pathogenesis. Many patients with FGID develop symptoms following ingestion of fermentable sugars; we investigated the associations between symptoms and intestinal gas production following sugar provocation tests to elucidate mechanisms of FGID. We performed fructose and lactose breath tests in 2042 patients with a diagnosis of FGID (based on Rome III criteria), referred to a gastroenterology practice from January 2008 through December 2011. Medical and diet histories were collected from all subjects. Breath samples were collected before and each hour after, for 5 hours, subjects ingested fructose (35 g) and lactose (50 g) dissolved in 300 mL water. Hydrogen and methane gas concentrations were measured and GI and non-GI symptoms were registered for 5 hours following sugar ingestion. Symptom and gas time profiles were compared, treelet transforms were used to derive data-related symptom clusters, and the symptom severity of the clusters were analyzed for their association with breath...Continue Reading

Associated Clinical Trials

Citations

Feb 12, 2019·The American Journal of Gastroenterology·Søren S OlesenUNKNOWN Scandinavian Baltic Pancreatic Club
Mar 4, 2020·Nutrition Research Reviews·Chloé MelchiorGuillaume Gourcerol
Apr 21, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Isabelle A M van ThielRene M van den Wijngaard
Jul 2, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Johann HammerKarin Hammer
Dec 14, 2018·Journal of Clinical Medicine·Karolina Skonieczna-ŻydeckaIgor Łoniewski
Sep 22, 2020·Clinical and Translational Gastroenterology·Clive H Wilder-SmithSøren S Olesen
Nov 8, 2018·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Ayesha ShahGerald Holtmann
Nov 7, 2019·Scandinavian Journal of Gastroenterology·Clive H Wilder-SmithSøren S Olesen
Aug 18, 2020·Journal of Pediatric Gastroenterology and Nutrition·Francisco AlliendeLorena Rodriguez
Jan 10, 2021·Scientific Reports·Sharon ErdrichJoanna E Harnett
Dec 22, 2020·Therapeutic Advances in Gastroenterology·Sharon ErdrichJoanna E Harnett
Apr 13, 2021·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Clive Wilder-SmithEric Chun Yong Chan

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