Fermentation, isolation, and antitumor activity of sterigmatocystins.

Antimicrobial Agents and Chemotherapy
W T BradnerF A O'Herron

Abstract

In a screening program for antitumor substances from microbial fermentations, a compound was isolated from the mycelium of an Aspergillus species which proved to be the mycotoxin 5-methoxysterigmatocystin. This and the subsequently isolated sterigmatocystin gave significant inhibition of the transplanted mouse leukemias P-388 and L-1210. Preparation and testing of several derivatives of 5-methoxysterigmatocystin suggest that certain functions in the molecule are essential for tumor inhibition. Although slight antitumor effects have been reported for the chemically related aflatoxins, we believe this is the first report of antitumor activity of sterigmatocystins.

References

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Mar 1, 1969·Food and Cosmetics Toxicology·I F Purchase, J J van der Watt

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Citations

May 24, 2012·Chemical Reviews·Kye-Simeon Masters, Stefan Bräse
Nov 13, 2003·Chembiochem : a European Journal of Chemical Biology·Carla BassarelloLuigi Gomez-Paloma
Oct 12, 2004·Il Farmaco·Yaseen A Al-SoudNajim A Al-Masoudi
Dec 5, 2008·Microbiology and Molecular Biology Reviews : MMBR·Sangjin Hong, Peter L Pedersen
Jun 19, 2018·Applied Microbiology and Biotechnology·Gaspar Banfalvi
Jun 27, 2019·Current Medicinal Chemistry·Xue-Mei HouChang-Lun Shao
Dec 30, 2003·Journal of Natural Products·E M Kithsiri WijeratneA A Leslie Gunatilaka
Dec 29, 2004·Journal of Natural Products·Jian HeA A Leslie Gunatilaka

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