Fermented Brown Rice Extract Causes Apoptotic Death of Human Acute Lymphoblastic Leukemia Cells via Death Receptor Pathway

Applied Biochemistry and Biotechnology
Yukiko HorieKyoji Morita

Abstract

Mixture of brown rice and rice bran fermented with Aspergillus oryzae, designated as FBRA, has been reported to reveal anti-carcinogenic and anti-inflammatory effects in rodents. Then, to test its potential anti-cancer activity, the aqueous extract was prepared from FBRA powder, and the effect of this extract on human acute lymphoblastic leukemia Jurkat cells was directly examined. The exposure to FBRA extract reduced the cell viability in a concentration- and time-dependent manner. The reduction of the cell viability was accompanied by the DNA fragmentation, and partially restored by treatment with pan-caspase inhibitor. Further studies showed that FBRA extract induced the cleavage of caspase-8, -9, and -3, and decreased Bcl-2 protein expression. Moreover, the expression of tBid, DR5, and Fas proteins was enhanced by FBRA extract, and the pretreatment with caspase-8 inhibitor, but not caspase-9 inhibitor, restored the reduction of the cell viability induced by FBRA extract. These findings suggested that FBRA extract could induce the apoptotic death of human acute lymphoblastic leukemia cells probably through mainly the death receptor-mediated pathway and supplementarily through the tBid-mediated mitochondrial pathway, proposin...Continue Reading

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Citations

May 20, 2016·Applied Biochemistry and Biotechnology·Hui LiHuiling Zheng
Nov 1, 2016·Applied Biochemistry and Biotechnology·Hui LiXin Song
Jun 10, 2017·Expert Review of Anticancer Therapy·Parnaz MerikhianKeivan Majidzadeh-A
Jun 18, 2019·Australian and New Zealand Journal of Public Health·Samantha Battams, Fiona Robards
Jun 5, 2019·Archives of Suicide Research : Official Journal of the International Academy for Suicide Research·Laura Finlayson-ShortJo Robinson
Jun 18, 2017·Annals of Global Health·David C Schwebel
Dec 19, 2017·Annals of Global Health·Shalini NavaleLisa R Hirschhorn
Feb 10, 2017·Applied Biochemistry and Biotechnology·Sung-Jo KimHyun Sik Jun
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Jan 8, 2021·Foods·Marco SpaggiariMaría Dolores Del Castillo Bilbao
Jul 1, 2019·Comprehensive Reviews in Food Science and Food Safety·Ahmed S M SalehZhigang Xiao

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