Ferret hepatitis E virus infection induces acute hepatitis and persistent infection in ferrets

Veterinary Microbiology
Tian-Cheng LiTakaji Wakita

Abstract

Ferret hepatitis E virus (HEV), a novel hepatitis E virus, has been identified in ferrets. However, the pathogenicity of ferret HEV remains unclear. In the present study, we compared the HEV RNA-positivity rates and alanine aminotransferase (ALT) levels of 63 ferrets between before and after import from the US to Japan. We found that the ferret HEV-RNA positivity rates were increased from 12.7% (8/63) to 60.3% (38/63), and ALT elevation was observed in 65.8% (25/38) of the ferret HEV RNA-positive ferrets, indicating that ferret HEV infection is responsible for liver damage. From long term-monitoring of ferret HEV infection we determined that this infection in ferrets exhibits three patterns: sub-clinical infection, acute hepatitis, and persistent infection. The ALT elevation was also observed in ferret HEV-infected ferrets in a primary infection experiment. These results indicate that the ferret HEV infection induced acute hepatitis and persistent infection in ferrets, suggesting that the ferrets are a candidate animal model for immunological as well as pathological studies of hepatitis E.

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Citations

Aug 17, 2016·Viruses·Sébastien LhommeJacques Izopet
Apr 26, 2017·Journal of Virological Methods·Tian-Cheng LiTakaji Wakita
Dec 20, 2017·Frontiers in Microbiology·Yuchen NanEn-Min Zhou
Oct 5, 2018·Annual Review of Animal Biosciences·Scott P Kenney, Xiang-Jin Meng
May 8, 2018·Cold Spring Harbor Perspectives in Medicine·Tian-Cheng Li, Takaji Wakita
Jun 21, 2019·Viruses·Laura CorneilliePhilip Meuleman
May 26, 2017·Oncotarget·Andrea KroekerXiangguo Qiu
Jul 11, 2020·Transboundary and Emerging Diseases·Wenjing ZhangTian-Cheng Li
May 5, 2017·Food and Environmental Virology·Nigel CookReimar Johne
Jul 11, 2017·EFSA Journal·UNKNOWN EFSA Panel on Biological Hazards (BIOHAZ)Rosina Girones
Sep 30, 2019·Virus Research·Ibrahim M SayedMohamed A El-Mokhtar

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