Ferrets as Models for Influenza Virus Transmission Studies and Pandemic Risk Assessments

Emerging Infectious Diseases
Jessica A BelserHui-Ling Yen

Abstract

The ferret transmission model is extensively used to assess the pandemic potential of emerging influenza viruses, yet experimental conditions and reported results vary among laboratories. Such variation can be a critical consideration when contextualizing results from independent risk-assessment studies of novel and emerging influenza viruses. To streamline interpretation of data generated in different laboratories, we provide a consensus on experimental parameters that define risk-assessment experiments of influenza virus transmissibility, including disclosure of variables known or suspected to contribute to experimental variability in this model, and advocate adoption of more standardized practices. We also discuss current limitations of the ferret transmission model and highlight continued refinements and advances to this model ongoing in laboratories. Understanding, disclosing, and standardizing the critical parameters of ferret transmission studies will improve the comparability and reproducibility of pandemic influenza risk assessment and increase the statistical power and, perhaps, accuracy of this model.

References

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Citations

Sep 19, 2019·Immunity & Ageing : I & a·Stephen N CrookeRichard B Kennedy
Jul 10, 2019·Annual Review of Virology·Pradeep D UchilWalther Mothes
Dec 29, 2019·The Journal of Biological Chemistry·Mari NumataDennis R Voelker
Feb 23, 2020·Biology·Ariane NeumannMaren von Köckritz-Blickwede
Dec 25, 2019·Cold Spring Harbor Perspectives in Medicine·Jessica A BelserTaronna R Maines
Mar 2, 2019·Tropical Medicine and Infectious Disease·Joanna A Pulit-PenalozaTaronna R Maines
Feb 5, 2019·The Journal of Infectious Diseases·Gabriele Neumann, Yoshihiro Kawaoka
Dec 25, 2019·Cold Spring Harbor Perspectives in Medicine·Brian R WasikColin R Parrish
Jan 25, 2021·The Journal of Biological Chemistry·Mari NumataDennis R Voelker
Apr 29, 2021·Nature Microbiology·Thomas P PeacockWendy S Barclay
Jun 3, 2021·Viruses·Thi-Quyen NguyenYoung-Ki Choi
Aug 7, 2021·Vaccines·Ericka Kirkpatrick Roubidoux, Stacey Schultz-Cherry

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Methods Mentioned

BETA
PCR

Software Mentioned

Influenza Risk Assessment Tool Tool for Influenza Pandemic Ris...

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