Ferritin-induced relaxation in tissues: an in vitro study

Journal of Magnetic Resonance Imaging : JMRI
Yves GossuinP Gillis

Abstract

To study in vitro the proton relaxation induced in tissues by ferritin, the iron-storing protein of mammals. Nuclear magnetic relaxation dispersion (NMRD) profiles of liver and spleen from control and iron-overloaded mice are compared with NMRD profiles of ferritin and Fercayl-a ferritin-like akaganeite particle-in aqueous solutions or in 1% agarose gel. The relaxation of water protons induced by ferritin and Fercayl in 1% agarose gel is comparable with the relaxation of aqueous solutions of the same compounds, but slower than the relaxation of liver and spleen. The gel is not a good model of tissues containing ferritin. The longitudinal NMRD profiles of control and iron-overloaded liver and spleen are almost identical: ferritin accumulation has only a slight effect on longitudinal relaxation. The transverse NMRD profiles of liver and spleen tissues are linear, but the slope of the linear regression is larger for iron-loaded organs than for control ones, which is a consequence of a higher ferritin concentration in the former. However, the correlation between the slope of the transverse NMRD profiles and the iron concentration is not very good, probably because transverse relaxation is modified by the clustering of ferritin in c...Continue Reading

References

Oct 1, 1992·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J VymazalG Di Chiro
May 1, 1991·Radiology·J M GomoriH Rotem
Dec 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A G SmithD Dinsdale
Oct 1, 1986·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S H KoenigT J Peters
Feb 1, 1982·AJR. American Journal of Roentgenology·F H DoyleD J Gilderdale
Jul 1, 1995·Journal of Magnetic Resonance Imaging : JMRI·R A BrooksV Tran
Sep 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R J OrdidgeJ A Helpern
Jul 1, 1993·Journal of Magnetic Resonance Imaging : JMRI·J W BulteJ A Frank
Apr 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G BartzokisS R Marder
Jul 31, 1996·Biochimica Et Biophysica Acta·P M Harrison, P Arosio
May 1, 1996·Movement Disorders : Official Journal of the Movement Disorder Society·F Q YeW R Martin
Jul 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J VymazalR A Brooks
Jul 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·F Q YeP S Allen
Apr 1, 1997·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J W BulteJ A Frank
Oct 30, 1998·Magma·S I MavrogeniD Kermastinos
Feb 19, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Y GossuinP Gillis
Mar 10, 2001·Journal of Magnetic Resonance Imaging : JMRI·A FenziR Colombari
Sep 11, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Y GossuinP Gillis
Oct 24, 2002·Blood·Gary M BrittenhamUNKNOWN National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Workshop
Dec 5, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yves GossuinFrancesco Lo Bue
Feb 21, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Paul R ClarkTimothy G St Pierre

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Citations

May 27, 2010·Brain Imaging and Behavior·Stephen CorreiaBenjamin D Greenberg
Dec 21, 2006·Topics in Magnetic Resonance Imaging : TMRI·Hernán JaraAlexander M Norbash
Feb 14, 2016·International Journal of Hematology·Gabriel C CamargoIlan Gottlieb
Mar 11, 2008·Biophysical Journal·Kevin M BennettAlan P Koretsky
Jan 28, 2009·Human Brain Mapping·Patrice PéranUmberto Sabatini
Jan 6, 2010·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Yves GossuinAlain Roch
Jul 3, 2009·Contrast Media & Molecular Imaging·Aline HocqYves Gossuin
Mar 3, 2007·NMR in Biomedicine·Yves GossuinAline Hocq
Dec 7, 2007·Journal of Magnetic Resonance Imaging : JMRI·Patrice PéranUmberto Sabatini
May 26, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Abby E DeansDaniel H Turnbull
Feb 28, 2007·Journal of Magnetic Resonance Imaging : JMRI·Pippa StoreyCynthia K Rigsby
Oct 13, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Venkatesh ManiZahi A Fayad
Jun 27, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·John C WoodRex Moats
Jan 26, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Preeti A SukerkarThomas J Meade
Sep 20, 2012·Contrast Media & Molecular Imaging·Monika DezortovaMilan Hajek
Jun 24, 2014·Contrast Media & Molecular Imaging·Aline HocqYves Gossuin
May 1, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jens H JensenGary M Brittenham
Dec 27, 2005·Magnetic Resonance Imaging·Yves GossuinLionel Bartel
Feb 12, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Gisela GuthausenHarald Horn
Jan 4, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Valeria BitontoJuan Carlos Cutrin

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