Ferritin may mediate SIN-1-induced protection against oxidative stress

Nitric Oxide : Biology and Chemistry
S Oberle, H Schröder

Abstract

In porcine aortic endothelial cells, a 20-h incubation with hydrogen peroxide (0.5 mM) markedly reduced the number of viable cells. A 6-h preincubation with linsidomine (SIN-1, 0.5 mM) protected endothelial cells from hydrogen peroxide-dependent cytotoxicity and increased the surviving endothelial cell fraction by 85%. This protection was associated with a 2.5-fold induction of ferritin heavy chain mRNA and ferritin protein by SIN-1. The nitric oxide donor glyceryl trinitrate was also found to induce transcriptional and translational expression of ferritin heavy chain. A protective effect comparable to SIN-1 was observed when preincubating the cells with iron-free apoferritin (1 mg/ml). These findings suggest that ferritin induction, presumably via release of nitric oxide, may be a mechanism underlying long-term cytoprotection by SIN-1 against oxidative stress.

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Citations

Feb 1, 2002·Biochemical and Biophysical Research Communications·Stefanie OberleHenning Schröder
Jul 25, 2000·Biochemical and Biophysical Research Communications·N Grosser, H Schröder
May 1, 2001·The European Journal of Neuroscience·M XieH H Kerschbaum
Dec 19, 2008·American Journal of Therapeutics·Henning Schröder
Feb 6, 2004·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Georg BerndtHenning Schröder
Sep 28, 2010·Journal of Cellular Biochemistry·Su Hee HanSung-Jin Kim
Aug 21, 2003·Biochemical and Biophysical Research Communications·Nina GrosserHenning Schröder
Sep 6, 2005·Journal of Atherosclerosis and Thrombosis·Qaisar Khan, Jawahar L Mehta
Oct 30, 1998·Biochemical and Biophysical Research Communications·T Polte, H Schröder
Jul 16, 1999·Biochemical and Biophysical Research Communications·S OberleH Schröder
Nov 14, 1998·Biochemical and Biophysical Research Communications·B Hinz, H Schröder
Sep 19, 2003·Archives of Biochemistry and Biophysics·Ayesha RahmanMohammad Athar
May 16, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·T PolteH Schröder
Jun 28, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Nina Grosser, Henning Schröder
Apr 24, 2003·Experimental Biology and Medicine·Stefanie OberleHenning Schröder
Jan 21, 2000·Free Radical Biology & Medicine·M S JoshiJ R Lancaster

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