Ferritin trends do not predict changes in total body iron in patients with transfusional iron overload

American Journal of Hematology
Mammen PuliyelThomas Coates

Abstract

Ferritin levels and trends are widely used to manage iron overload and assess the efficacy of prescribed iron chelation in patients with transfusional iron loading. A retrospective cohort study was conducted in 134 patients with transfusion-dependent anemia, over a period of up to 9 years. To determine whether the trends in ferritin adequately reflect the changes in total body iron, changes in ferritin between consecutive liver iron measurements by magnetic resonance imaging (MRI) were compared to changes in liver iron concentrations (LIC), a measure of total body iron. The time period between two consecutive LIC measurements was defined as a segment. Trends in ferritin were considered to predict the change in LIC within a segment if the change in one parameter was less than twofold that of the other, and was in the same direction. Using the exclusion criteria detailed in methods, the trends in ferritin were compared to changes in LIC in 358 segments. An agreement between ferritin trends and LIC changes was found in only 38% of the 358 segments examined. Furthermore, the change in ferritin was in opposite direction to that of LIC in 26% of the segments. Trends in ferritin were a worse predictor of changes in LIC in sickle cell ...Continue Reading

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Citations

Jun 12, 2014·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Maciej W GarbowskiJohn B Porter
Jul 30, 2014·Hematology/oncology Clinics of North America·John C Wood
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Mar 15, 2015·British Journal of Haematology·John C Wood
Feb 20, 2015·Hematology·John C Wood
May 18, 2016·Annals of the New York Academy of Sciences·Thomas D CoatesVasilios Berdoukas
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