Ferroptosis in Friedreich's Ataxia: A Metal-Induced Neurodegenerative Disease.

Biomolecules
Piergiorgio La RosaFiorella Piemonte

Abstract

Ferroptosis is an iron-dependent form of regulated cell death, arising from the accumulation of lipid-based reactive oxygen species when glutathione-dependent repair systems are compromised. Lipid peroxidation, mitochondrial impairment and iron dyshomeostasis are the hallmark of ferroptosis, which is emerging as a crucial player in neurodegeneration. This review provides an analysis of the most recent advances in ferroptosis, with a special focus on Friedreich's Ataxia (FA), the most common autosomal recessive neurodegenerative disease, caused by reduced levels of frataxin, a mitochondrial protein involved in iron-sulfur cluster synthesis and antioxidant defenses. The hypothesis is that the iron-induced oxidative damage accumulates over time in FA, lowering the ferroptosis threshold and leading to neuronal cell death and, at last, to cardiac failure. The use of anti-ferroptosis drugs combined with treatments able to activate the antioxidant response will be of paramount importance in FA therapy, such as in many other neurodegenerative diseases triggered by oxidative stress.

References

Nov 1, 1976·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·G Sanchez-CasisA Barbeau
Nov 1, 1992·Journal of Neurochemistry·B Halliwell
Jan 1, 1991·Annual Review of Neuroscience·R W Oppenheim
Jan 1, 1989·Chemico-biological Interactions·G Minotti, S D Aust
Mar 29, 1985·Biochimica Et Biophysica Acta·F UrsiniC Gregolin
Nov 1, 1980·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·J B LamarcheB Lemieux
Sep 1, 1994·Journal of Neurochemistry·M GerlachM B Youdim
Oct 17, 1996·The New England Journal of Medicine·A DürrM Koenig
Jan 14, 2000·Journal of Medical Genetics·M B DelatyckiS M Forrest
Aug 10, 2000·American Journal of Human Genetics·J AdamecG Isaya
Dec 13, 2000·Neurology·J B SchulzM B Bogdanov
Dec 13, 2000·Neurology·M EmondM Pandolfo
Dec 12, 2001·European Journal of Clinical Investigation·F PiemonteE Bertini
Feb 2, 2002·Human Molecular Genetics·Patrizia CavadiniGrazia Isaya
Feb 20, 2002·FEBS Letters·Carlos J MirandaMassimo Pandolfo
Sep 18, 2002·The Journal of Biological Chemistry·Hiromi SasakiShiro Bannai
Nov 19, 2002·The Journal of Biological Chemistry·E Christine PietschSuzy V Torti
Apr 2, 2003·Human Molecular Genetics·Emmanuel LesuisseAndrew Dancis
Feb 27, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Delphine SimonHélène Puccio
Mar 25, 2004·Neurochemical Research·J L BradleyJ M Cooper
May 5, 2004·The Journal of Biological Chemistry·Taejin Yoon, J A Cowan
Jul 28, 2004·Journal of Molecular Biology·Fadi Bou-AbdallahN Dennis Chasteen
Dec 22, 2004·Biochemistry·Yanan HeTimothy L Stemmler
Jun 30, 2006·Journal of Neurochemistry·Barry Halliwell
Nov 15, 2006·The Journal of Cell Biology·Sabrina BüttnerFrank Madeo
Dec 15, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·José V LlorensMaria D Moltó
Apr 24, 2007·Free Radical Biology & Medicine·Anne-Laure BulteauEmmanuel Lesuisse
Sep 21, 2007·Neurology·UNKNOWN Parkinson Study Group PRECEPT Investigators
Nov 6, 2007·Lancet Neurology·Paul H GordonUNKNOWN Western ALS Study Group
Jan 11, 2008·Proceedings of the National Academy of Sciences of the United States of America·Peter R AndersonJohn P Phillips
Feb 19, 2008·Free Radical Biology & Medicine·Verónica IrazustaJordi Tamarit

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Citations

Mar 7, 2021·IUBMB Life·Jordi TamaritJoaquim Ros
Jul 25, 2021·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Sara PetrilloFiorella Piemonte

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