Abstract
Artemisinin-based combination therapies (ACTs) are the recommended first-line treatment for uncomplicated Plasmodium falciparum malaria. Ferroquine is a new combination partner for fast-acting ACTs such as artesunate. We aimed to assess different doses of ferroquine in combination with artesunate against uncomplicated P falciparum malaria in a heterogeneous population in Africa. We did a phase 2, multicentre, parallel-group, double-blind, randomised, dose-ranging non-inferiority trial at eight African hospitals (two in Gabon, three in Burkina Faso, one in Benin, and two in Kenya). We recruited patients presenting with acute P falciparum monoinfection (1000-200,000 parasites per μL), and a central body temperature of at least 37·5°C or history of fever in the past 24 h. We assessed patients in two sequential cohorts: cohort 1 contained adults (bodyweight >50 kg) and adolescents (aged ≥14 years, >30 kg), and cohort 2 contained children (aged 2-13 years, 15-30 kg). We randomly assigned patients (1:1:1:1) to receive artesunate 4 mg/kg per day plus ferroquine 2 mg/kg, 4 mg/kg, or 6 mg/kg, given double-blind once per day for 3 days, or ferroquine monotherapy 4 mg/kg per day given single-blind (ie, allocation was only masked from the ...Continue Reading
References
Nov 26, 1997·Journal of Medicinal Chemistry·C BiotJ S Brocard
Apr 11, 2001·Parasitology Research·L DelhaesD Dive
Feb 8, 2002·Nature·Robert G Ridley
Mar 21, 2002·Tropical Medicine & International Health : TM & IH·B PradinesD Parzy
Feb 27, 2003·Antimicrobial Agents and Chemotherapy·Steffen BorrmannPeter G Kremsner
Mar 11, 2003·Transactions of the Royal Society of Tropical Medicine and Hygiene·S BorrmannP G Kremsner
Mar 26, 2003·The Journal of Antimicrobial Chemotherapy·Christiane AttekePhilippe Deloron
Jul 21, 2004·Lancet·Peter Gottfried Kremsner, Sanjeev Krishna
Dec 22, 2004·Drugs·Timothy M E DavisKenneth F Ilett
May 27, 2005·Antimicrobial Agents and Chemotherapy·Ing-Kye SimKenneth F Ilett
Jan 18, 2006·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Wassim DaherDaniel Dive
Mar 7, 2006·Current Molecular Medicine·Benjamin Mordmüller, Peter G Kremsner
Feb 16, 2007·Tropical Medicine & International Health : TM & IH·Elizabeth A AshleyFrançois Nosten
Jun 29, 2007·Malaria Journal·Marion BarendsFrançois Nosten
Jul 25, 2007·The Lancet Infectious Diseases·Nicholas J White
May 29, 2008·Antimicrobial Agents and Chemotherapy·Maud HenryBruno Pradines
Jul 5, 2008·European Journal of Clinical Pharmacology·L T Diem ThuyK Na-Bangchang
Dec 10, 2008·The New England Journal of Medicine·Harald NoedlUNKNOWN Artemisinin Resistance in Cambodia 1 (ARC1) Study Consortium
Jun 1, 2010·BMJ : British Medical Journal·Hugh Reyburn
Aug 31, 2010·Malaria Journal·Sankar SridaranVenkatachalam Udhayakumar
Mar 3, 2011·Malaria Journal·Ghyslain Mombo-NgomaBertrand Lell
Jul 7, 2011·Antimicrobial Agents and Chemotherapy·Jutta MarfurtRic N Price
Sep 7, 2011·Parasite : Journal De La Société Française De Parasitologie·C BiotD Dive
Oct 19, 2011·Malaria Journal·Matthias FrankPeter G Kremsner
Mar 21, 2012·Antimicrobial Agents and Chemotherapy·Christian SupanBertrand Lell
Dec 12, 2012·Transactions of the Royal Society of Tropical Medicine and Hygiene·Cho NaingJadon Y R Wong
Dec 19, 2012·Malaria Journal·George O AdjeiBamenla Q Goka
Jul 23, 2014·Antimicrobial Agents and Chemotherapy·B R MooreT M E Davis
Nov 13, 2014·The New England Journal of Medicine·Michael HawkesKevin C Kain
Jan 8, 2015·Expert Opinion on Investigational Drugs·Jana HeldAndrea Kreidenweiss
Citations
Oct 22, 2015·Chemical Society Reviews·Gérard JaouenSiden Top
Sep 8, 2015·The Lancet Infectious Diseases·Timothy Nc Wells, Rob Hooft van Huijsduijnen
May 19, 2016·Expert Opinion on Pharmacotherapy·Nicholas J White
Jun 3, 2016·The Journal of Infectious Diseases·David S KhouryMiles P Davenport
Sep 15, 2016·Malaria Journal·James S McCarthyJörg J Möhrle
Nov 5, 2016·Infectious Diseases of Poverty·Akshaya Srikanth BhagavathulaAbdulla Shehab
Nov 27, 2016·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Abraham Sunday AlabiUNKNOWN CERMEL TB CapDev Group
Nov 26, 2015·Memórias do Instituto Oswaldo Cruz·Nicolli Bellotti de SouzaAntoniana Ursine Krettli
Nov 7, 2016·Journal of Inorganic Biochemistry·Sofia TapanelliCarlo Santini
Jul 5, 2017·Chemical Communications : Chem Comm·Christian ArtnerBernhard K Keppler
Jul 20, 2017·CPT: Pharmacometrics & Systems Pharmacology·F T MusuambaI Skottheim Rusten
Feb 15, 2018·Antimicrobial Agents and Chemotherapy·Farhana MosaddequeKenji Hirayama
Nov 23, 2017·Scientific Reports·Artem KondratskyiNatalia Prevarskaya
Oct 23, 2018·The Prostate·Benedikt KranzbühlerDaniel Eberli
Aug 24, 2018·F1000Research·Emily S Mathews, Audrey R Odom John
Jan 4, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Gowtham SubramanianRajesh Chandramohanadas
Aug 5, 2017·Nature Medicine·Benjamin BlascoDavid A Fidock
Aug 5, 2017·Nature Reviews. Disease Primers·Margaret A PhillipsTimothy N C Wells
Jul 20, 2017·The American Journal of Tropical Medicine and Hygiene·Christian SupanDouglas S Walsh
Nov 30, 2019·Future Medicinal Chemistry·Ishan WadiAbhinav Sinha
Mar 27, 2018·Journal of Cellular Biochemistry·Elizabeth A HallClaire F Verschraegen
Jan 15, 2017·Malaria Journal·Jeremy N BurrowsTimothy N C Wells
Nov 24, 2019·Scientific Reports·Erik KoehneJana Held
May 29, 2018·Drugs·Elizabeth A Ashley, Aung Pyae Phyo
Jun 3, 2016·Expert Review of Anti-infective Therapy·Johannes MischlingerMichael Ramharter
Aug 16, 2018·MedChemComm·John Okombo, Kelly Chibale
Jan 6, 2021·Wiener klinische Wochenschrift·Michael RamharterPeter G Kremsner
Mar 5, 2021·Virologica Sinica·Jun LuoXiaofeng Guo
May 21, 2021·Malaria Journal·Yeka AdokeUNKNOWN FALCI Study Group
Jul 22, 2021·Natural Product Reports·Hai-Ning LyuJigang Wang
Jul 28, 2021·Expert Opinion on Pharmacotherapy·Erik KoehneAndrea Kreidenweiss
Sep 23, 2020·Journal of Medicinal Chemistry·Guang HuangYu Yuan
Oct 12, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Taryn M GoldingGregory S Smith
Nov 23, 2021·Drug Discovery Today·Faqian BuLiang Ouyang