Ferrous sulfate does not reduce serum levels of famotidine or cimetidine after concurrent ingestion

Clinical Pharmacology and Therapeutics
E S PartlowB B Hasinoff

Abstract

A series of randomized crossover studies were performed to determine whether there was a reduction in serum levels of cimetidine and famotidine when coingested with ferrous sulfate (300 mg). Coingestion of a ferrous sulfate tablet with cimetidine (300 mg) was associated with little reduction in serum cimetidine area under the curve (AUC) (mean versus mean, 20.8 versus 23.4 mumol.hr/L; mean percentage difference, -11%; 95% confidence interval [CI] of percentage difference, -26% to 4.2%) or peak concentration (Cmax) (mean versus mean, 5.1 versus 6.1 mumol/L; mean percentage difference, -16%; CI of percentage difference, -36% to 4%). Similarly, ferrous sulfate solution coingested with cimetidine caused little change in cimetidine AUC (mean versus mean, 19.9 versus 23.0 mumol.hr/L; mean percentage difference, -13%; CI of percentage difference, -34% to 7%) or Cmax (mean versus mean, 5.0 versus 5.0 mumol/L; mean percentage difference, 1%; CI of percentage difference, -18% to 20%). Concurrent ingestion of famotidine (40 mg) with a ferrous sulfate tablet did not result in significant reductions in serum famotidine AUC (mean versus mean, 1.78 versus 1.99 mumol.hr/L; mean percentage difference, -10%; CI of percentage difference, -34% to ...Continue Reading

References

Dec 15, 1992·Annals of Internal Medicine·N R CampbellN C Wong
Jan 1, 1992·British Journal of Clinical Pharmacology·N R CampbellD W McKay
Mar 1, 1991·British Journal of Clinical Pharmacology·N R Campbell, B B Hasinoff
Mar 1, 1991·British Journal of Clinical Pharmacology·M KaraN R Campbell
Oct 1, 1990·British Journal of Clinical Pharmacology·N R CampbellM Kara
May 1, 1990·Canadian Journal of Physiology and Pharmacology·R R CampbellN R Campbell
Mar 1, 1989·Clinical Pharmacology and Therapeutics·N R Campbell, B Hasinoff
Nov 28, 1970·British Medical Journal·P J NeuvonenK Björksten
Apr 1, 1983·Clinical Pharmacology and Therapeutics·M A OsmanP G Welling
Nov 1, 1993·Clinical Pharmacology and Therapeutics·K UenoI Nakata
May 1, 1993·Digestive Diseases and Sciences·N R CampbellK Granberg

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