Fertility and pregnancy outcome in women with congenital adrenal hyperplasia due to 21-hydroxylase deficiency

Human Reproduction
K HagenfeldtA Nordenskjöld

Abstract

Low pregnancy rate has been reported in women with congenital adrenal hyperplasia (CAH) and little information on pregnancy and children is known. In a Swedish study, 62 adult women with CAH, aged 18-63 years, and 62 age-matched controls were followed-up. Medical records, including those concerning pregnancies and deliveries, were examined and the 21-hydroxylase genotype of patients was noted. All women answered a questionnaire concerning sexual and reproductive health including health of the children. Pregnancy and delivery rates were significantly lower in women with CAH (P < 0.001, P < 0.0056, respectively), and the severity of the 21-hydroxylase-mutation correlated with the reduced number of children born. More women with salt-wasting CAH were single and had not attempted pregnancy. Pregnancies were normal except for a significantly increased incidence of gestational diabetes in CAH patients (P < 0.0024). The children had normal birthweight and no malformations were observed. A later follow-up of the children showed a normal intellectual and social development. The sex ratio of the offspring differed significantly, with 25% boys in the CAH group compared with 56% among controls (P < 0.016). CAH women had more gynaecological...Continue Reading

Citations

Jan 10, 2012·Endocrine·Henrik Falhammar, Marja Thorén
Dec 3, 2013·Journal of Obstetrics and Gynaecology of India·Alka KriplaniC Aminni Ariachery
Jun 6, 2013·Thyroid : Official Journal of the American Thyroid Association·Inka Miñambres DonaireRosa Corcoy Pla
Oct 25, 2008·Human Reproduction·William H James
Mar 11, 2010·Obstetrical & Gynecological Survey·Amber A Vos, Hein W Bruinse
Oct 27, 2010·International Journal of Pediatric Endocrinology·Stephanie A StoutDavid E Sandberg
Feb 12, 2010·International Journal of Pediatric Endocrinology·Todd D Nebesio, Erica A Eugster
Oct 29, 2010·International Journal of Pediatric Endocrinology·Phyllis W SpeiserPerrin C White
Sep 9, 2010·The Journal of Clinical Endocrinology and Metabolism·Phyllis W SpeiserUNKNOWN Endocrine Society
Aug 20, 2010·The Journal of Clinical Endocrinology and Metabolism·Wiebke ArltUNKNOWN United Kingdom Congenital Adrenal Hyperplasia Adult Study Executive (CaHASE)
Jan 23, 2013·The Journal of Clinical Endocrinology and Metabolism·Nils KroneUNKNOWN United Kingdom Congenital adrenal Hyperplasia Adult Study Executive (CaHASE)
Dec 14, 2011·European Journal of Endocrinology·Henrik FalhammarMarja Thorén
Oct 2, 2013·Indian Journal of Endocrinology and Metabolism·Mouna Feki MnifMohamed Abid
Jun 17, 2010·European Journal of Endocrinology·Ingrid NermoenKristian Løvås
Jan 29, 2014·European Journal of Pediatrics·Martina JürgensenUte Thyen
Apr 30, 2013·Steroids·Eunice MarumudiAriachery C Ammini
Nov 28, 2012·Journal of Pediatric Urology·Justine SchoberChristopher Woodhouse
Nov 20, 2012·Journal of Pediatric Urology·Peter LeeChristopher Woodhouse
Nov 26, 2011·Best Practice & Research. Clinical Endocrinology & Metabolism·David UnuaneKris Poppe
Jun 4, 2011·Pharmacology & Therapeutics·H L Claahsen-van der GrintenA R M M Hermus
Nov 17, 2015·Endocrinology and Metabolism Clinics of North America·Oksana LekarevMaria G Vogiatzi
Sep 5, 2015·Endocrine·Henrik FalhammarAnna Nordenström
Dec 21, 2013·Fertility and Sterility·David E ReichmanZev Rosenwaks
Jul 12, 2011·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Rosa M LaterzaHeinz Koelbl
Oct 4, 2016·Acta Diabetologica·Apolonia García-PattersonRosa Corcoy
Aug 4, 2016·Journal of Pediatric and Adolescent Gynecology·Rashmi KudesiaStaci E Pollack
May 17, 2014·Arquivos brasileiros de endocrinologia e metabologia·Rita Vasconcellos Weiss, Ruth Clapauch
Sep 5, 2015·F1000Research·Phyllis W Speiser
Dec 15, 2016·Endocrinology·Christopher HakimArpita K Vyas
Apr 18, 2019·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Xiao WangLiangshan Mu
Sep 12, 2012·Nature Reviews. Endocrinology·Silvia MonticoneWilliam E Rainey
Jan 1, 2009·Expert Review of Endocrinology & Metabolism·Karen Lin-SuMaria I New
Jul 2, 2009·The Journal of Clinical Endocrinology and Metabolism·Louise FrisénAgneta Nordenskjöld
Jan 19, 2010·The Journal of Clinical Endocrinology and Metabolism·Maud BidetF Kuttenn
Oct 31, 2012·Current Opinion in Endocrinology, Diabetes, and Obesity·Selma Feldman Witchel
Dec 16, 2016·Archives of Disease in Childhood·Christiaan F MooijNils Krone
Apr 1, 2020·International Journal of Molecular Sciences·Nathalia Lisboa GomesRod T Mitchell

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Cachexia

Cardiac cachexia is a syndrome associated with the progressive loss of muscle and fat mass. It most commonly affects patients with heart failure and can significantly decrease the quality of life and survival in these patients. Here is the latest research on cardiac cachexia.

Cachexia & Brown Fat

Cachexia is a condition associated with progressive weight loss due to severe illness. In cancer patients, it is proposed to occur as a result of tumor-induced energy wasting. Several proteins have been implicated in browning and depletion of white adipose tissue. Here is the latest research on cachexia and brown fat.