Fertility following treatment of high-grade malignant bone and soft tissue tumors in young adults

Molecular and Clinical Oncology
Manabu HoshiHiroaki Nakamura

Abstract

This study was conducted to investigate marriage and fertility in long-term survivors with high-grade bone and soft tissue tumors following chemotherapy. We reviewed issues related to fertility in 47 patients (24 men and 23 women) who had survived for >5 years. The median age at diagnosis was 18.0±8.9 years and the mean duration of follow-up 11.0 years. We investigated the proportions of married subjects (number of married/total number of subjects) and fertile subjects (number who had fathered or conceived offspring/total number of subjects), the interval between first delivery and last chemotherapy, type of delivery, congenital deformities in the offspring and the association between cumulative dose of chemotherapeutic agents and subsequent reproduction. The final proportions of married and fertile subjects following sarcoma treatment were 36.2% (17/47) and 29.8% (14/47), respectively. Two subjects had fathered and 8 had conceived a total of 15 offspring. The proportion of fertile men was significantly lower compared to that of women. The mean interval between the last chemotherapy and the first delivery was 9.5 years. Of the 10 first births, 6 were normal transvaginal deliveries and 4 were caesarean sections (1 was a medical ...Continue Reading

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Citations

Jan 23, 2016·International Journal of Clinical Oncology·Tsukasa YonemotoTakeshi Ishii
Mar 28, 2021·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Jiang YangNiu Xiaohui

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