PMID: 641947Apr 1, 1978Paper

Fertility in 47,XXX and 45,X patients

Journal of Medical Genetics
J Dewhurst

Abstract

Female patients with a sex chromosome abnormality may be fertile. In patients with a 47,XXX cell line there appears to be an increased risk of a cytogenetically abnormal child but the extent of this risk cannot yet be determined; it is probably lower in the non-mosaic 47,XXX patient than the mosaic 46,XX/47,XXX one. Patients with a 45,X cell line rarly become pregnant, and when they do they appear to have a high risk of an abnormal child or repeated unsuccessfuly pregnancies; this risk is certainly exaggerated by the method of reporting; when the poor reproductive perforamcne is first identified leading to the recognition of the maternal cytogenetic fault, the reproductive failure rate is naturally high; when the maternal fault is first identified and the reproductive history then established far better results are evident.

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Citations

Jan 1, 1988·Archives of Gynecology and Obstetrics·D GlaserI H Pawlowitzki
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May 1, 1983·Clinical Genetics·J P FrynsH van den Berghe

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