Fertility in male patients with seronegative spondyloarthropathies treated with infliximab

Joint, Bone, Spine : Revue Du Rhumatisme
Ioanna SaougouAlexandros A Drosos

Abstract

The majority of patients with ankylosing spondylitis (AS) and psoriatic arthritis (PsA) are affected during their peak reproductive years. Tumor necrosis factor (TNF)α plays a pivotal role in the pathogenesis of both diseases. Today, anti-TNFα blockers are an essential treatment for these patients. To identify male patients who achieved pregnancy development during their management with anti-TNFα blockers (infliximab). We reviewed the data of 65 patients with AS and 30 patients with PsA who were followed-up in our rheumatology outpatients clinic and they were on infliximab therapy between January 2001 and December 2010. We identified overall seven male patients with AS and three male patients with PsA who had fathered 14 healthy infants. Moreover, we recognized one man with PsA who was on infliximab and on concomitant therapy with MTX at the time of conception, whose wife had to proceed to therapeutic abortion due to congenital abnormalities of the fetus (hydrocephalia), while she was on the first trimester of pregnancy. We described male patients with AS and PsA who demonstrated no fertility problems while they were on infliximab treatment. The data designated in this report provide some supportive evidence for the safe use of...Continue Reading

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Citations

Mar 29, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Júlio Maria Fonseca ChebliAdérson Omar Mourão Cintra Damião
Jan 21, 2014·Joint, Bone, Spine : Revue Du Rhumatisme·Theodora E MarkatseliAlexandros A Drosos
Sep 10, 2014·Alimentary Pharmacology & Therapeutics·H SchulzeA Dignass
Nov 4, 2016·The American Journal of Gastroenterology·Michael Due LarsenBente Mertz Nørgård
Dec 20, 2013·Rheumatology·Kimme L Hyrich, Suzanne M M Verstappen
Mar 8, 2017·Inflammatory Bowel Diseases·Anne GrosenStephen B Hanauer
May 18, 2016·Reproduction, Fertility, and Development·Nicola A PascarelliGiulia Collodel
Jun 21, 2017·Terapevticheskiĭ arkhiv·P A ShesternyaA O Vasilyeva
Jun 14, 2019·Therapeutic Advances in Gastroenterology·Sarah E ShannahanMark A Peppercorn

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