Fertility potential after unilateral orchiopexy: simultaneous testicular biopsy and orchiopexy in a cohort of 87 patients

The Journal of Urology
D CortesS Lindenberg

Abstract

We investigated the prognostic value of the number of spermatogonia per tubular cross section in a testicular biopsy specimen obtained at orchiopexy for unilateral cryptorchidism. A total of 87 consecutive 10 to 12-year-old cryptorchid boys underwent testicular biopsy simultaneously with unilateral orchiopexy. In adulthood 56 of the 87 patients agreed to measurement of serum follicle-stimulating hormone, luteinizing hormone, testosterone and testicular volume, and 54 provided specimens for semen analysis. The number of spermatogonia per tubular cross section correlated to the volume of the operated testis and total testicular volume in adulthood. Serum follicle-stimulating hormone negatively correlated to these volumes, sperm concentration and total sperm count. Contralateral testicular volume correlated to sperm concentration, total sperm count, and percent of living and mobile sperm. When biopsy revealed Sertoli cells only or 1 spermatogonium per 100 tubular cross sections, the age matched number of spermatogonia per tubular cross section was 1% or less. Of these patients 33% later presented with 5 million spermatozoa per ml. or less, no normal motility and generally lower sperm concentrations that those with more than 1 sper...Continue Reading

References

Jul 1, 1976·The New England Journal of Medicine·L I LipshultzP J Snyder
Sep 12, 1992·BMJ : British Medical Journal·E CarlsenN E Skakkebaek
Sep 1, 1992·Mathematical Biosciences·V Hutson, K Schmitt
Jan 1, 1990·Scandinavian Journal of Urology and Nephrology·D Cortes
Jan 1, 1987·European Journal of Pediatrics·F HadziselimovicM Buser
Apr 1, 1980·The British Journal of Surgery·J Eldrup, K Steven
Feb 1, 1983·The Journal of Urology·P F Alpert, R S Klein
Dec 1, 1982·European Journal of Pediatrics·E Hedinger
Jan 1, 1984·Urological Research·F HadziselimovićB Herzog
Apr 1, 1995·Journal of Pediatric Surgery·D CortesB L Beck
Jun 11, 1994·Lancet·N E SkakkebaekD de Kretser
Feb 1, 1993·Journal of Pediatric Surgery·M HjertkvistA Bergh
Dec 1, 1993·Fertility and Sterility·R C Martin-du Pan, A Campana
Jan 1, 1994·Clinical Endocrinology·M BergmannE Nieschlag

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Citations

Mar 19, 2004·Current Urology Reports·J C Trussell, Peter A Lee
Oct 11, 2005·Urologia Internationalis·Serdar H IskitTolga E Dağli
Aug 12, 2014·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Manuel NistalMiguel Reyes-Múgica
Aug 30, 2008·The Journal of Urology·Annick VogelsGuy A Bogaert
Aug 22, 2012·The Journal of Urology·Kate H KraftThomas F Kolon
Jan 28, 2019·Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation·Jorgen Thorup, Dina Cortes
Oct 6, 2020·Indian Journal of Surgical Oncology·Ahmed Osama MohamedKhalid ElMalik
Oct 12, 2000·Archives of Andrology·I SasagawaR Yanagimachi
Jun 15, 1999·BJU International·J LeissnerM Fisch
Dec 25, 2009·Reproductive Biomedicine Online·A WiserI Madgar

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