Fertility preservation in boys: recent developments and new insights †.

Human Reproduction Open
Ellen GoossensJ B Stukenborg

Abstract

Infertility is an important side effect of treatments used for cancer and other non-malignant conditions in males. This may be due to the loss of spermatogonial stem cells (SSCs) and/or altered functionality of testicular somatic cells (e.g. Sertoli cells, Leydig cells). Whereas sperm cryopreservation is the first-line procedure to preserve fertility in post-pubertal males, this option does not exist for prepubertal boys. For patients unable to produce sperm and at high risk of losing their fertility, testicular tissue freezing is now proposed as an alternative experimental option to safeguard their fertility. With this review, we aim to provide an update on clinical practices and experimental methods, as well as to describe patient management inclusion strategies used to preserve and restore the fertility of prepubertal boys at high risk of fertility loss. Based on the expertise of the participating centres and a literature search of the progress in clinical practices, patient management strategies and experimental methods used to preserve and restore the fertility of prepubertal boys at high risk of fertility loss were identified. In addition, a survey was conducted amongst European and North American centres/networks that ha...Continue Reading

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Citations

Dec 2, 2020·Human Reproduction·Rod T Mitchell
Apr 2, 2021·Cell and Tissue Research·Tanushree PatraMukesh Kumar Gupta
Apr 4, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anna Laura VoigtIna Dobrinski
May 13, 2021·Fertility and Sterility·Miriam FunkeKirsi Jahnukainen
Sep 3, 2021·Journal of Cancer Survivorship : Research and Practice·Alexandra SmithLarissa Nekhlyudov
Jan 15, 2022·Reproductive Sciences·Keykavos GholamiSeyed Mohammad Kazem Aghamir

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Methods Mentioned

BETA
biopsy
biopsies
sperm collection
xenografts
electron microscopy
xenografting

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