Fertility Preservation in Children and Adolescents With Cancer

Urology
Christopher J LongT F Kolon

Abstract

Advancements in oncologic therapy have increased long-term survival rates for children with childhood cancers. As survival has increased, the secondary effects of treatment have come into focus for patients and family. Infertility preservation in prepubertal children is a particularly difficult task as options are limited compared to adult counterparts with mature gametes. A systematic review of the published literature was conducted using keywords relevant to fertility preservation in the pediatric population undergoing oncologic treatment. We review the impact of cancer therapy upon gonadal function and identify the risk factors for future infertility in the prepubertal population. Treatment modifications that could modify the degree of potential damage to reproductive organs yet maintain oncologic principles were highlighted. Pubertal males and females have the opportunity to donate mature sperm or oocytes as do their adult counterparts; however, for the prepubertal child this is not the case. The options for these patients are considered investigational at this point and center on testicular tissue cryopreservation in males and oophorectomy vs ovarian cortical tissue cryopreservation in females. Infertility is an unfortunat...Continue Reading

References

Nov 19, 1987·The New England Journal of Medicine·J ByrneK Bragg
Oct 1, 1982·International Journal of Radiation Oncology, Biology, Physics·H Kubo, W U Shipley
Nov 22, 1994·Proceedings of the National Academy of Sciences of the United States of America·R L Brinster, J W Zimmermann
Sep 1, 1993·Archives of Disease in Childhood·J L PedersenN E Skakkebaek
Oct 27, 1998·Journal of Pediatric Hematology/oncology·M L SchmiegelowJ R Müller
Jan 29, 1999·Endocrinology and Metabolism Clinics of North America·S Howell, S Shalet
Mar 22, 2002·BJOG : an International Journal of Obstetrics and Gynaecology·Louise E BathHilary O D Critchley
Mar 29, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Leslie R SchoverSima Jeha
Sep 25, 2002·International Journal of Andrology·S J Howell, S M Shalet
Nov 7, 2003·The Journal of Clinical Endocrinology and Metabolism·Elisabeth C LarsenAnders Nyboe Andersen
Nov 13, 2004·The Journal of Urology·Hans G PohlH Gil Rushton
Dec 23, 2004·Endocrine-related Cancer·H K Gleeson, S M Shalet
Dec 24, 2004·AJR. American Journal of Roentgenology·Christian HohlJoachim E Wildberger
Mar 31, 2006·Pediatric Blood & Cancer·Tress GoodwinGary V Dahl
Sep 16, 2006·Pediatric Blood & Cancer·Catherine J PoirotLaurence Brugieres
Apr 21, 2007·Science·Ralph L Brinster
Oct 25, 2007·Chemotherapy·M L Pereira, F Garcia e Costa
Nov 29, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·Mi HouKirsi Jahnukainen
Jul 11, 2008·Human Reproduction·Richard A AndersonW Hamish B Wallace
Sep 18, 2008·European Journal of Endocrinology·Eveline M DelemarreHenriette A Delemarre-van de Waal
Jan 9, 2009·Pediatric Radiology·Dianna M E BardoMario F Zaritzky
Mar 25, 2009·International Journal of Radiation Oncology, Biology, Physics·Jennifer Y Wo, Akila N Viswanathan
Apr 15, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel M GreenLeslie L Robison
Oct 31, 2009·BJOG : an International Journal of Obstetrics and Gynaecology·K T SchmidtA N Andersen
Dec 2, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel M GreenLeslie L Robison
Dec 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Xin WuRalph L Brinster
Feb 2, 2010·European Urology·Gianluca GiannariniGiorgio Pizzocaro
Jun 16, 2011·JAMA : the Journal of the American Medical Association·Hooman Sadri-ArdekaniAns M M van Pelt
Apr 5, 2012·The Journal of Clinical Endocrinology and Metabolism·Mark F H BroughamW Hamish B Wallace

❮ Previous
Next ❯

Citations

Apr 24, 2016·Urology·Nicholas G Cost, Jeffrey A Stock
Nov 1, 2016·MMW Fortschritte der Medizin·Frank-Michael Köhn, Hans-Christian Schuppe
Jan 19, 2018·Journal of Adolescent and Young Adult Oncology·Chiara GertosioMauro Bozzola
Apr 6, 2018·Pediatric Surgery International·Rebecca M RenteaSohail R Shah
Jun 7, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lisa B KenneyDaniel M Green
Aug 9, 2017·Current Opinion in Obstetrics & Gynecology·Kate McCracken, Leena Nahata
Nov 15, 2016·The Journal of Urology·Armando J Lorenzo
Jul 19, 2018·Obstetrics & Gynecology Science·Yodo Sugishita, Nao Suzuki
Jul 17, 2018·BioMed Research International·Marta R BizicMiroslav L Djordjevic
Feb 1, 2019·Hormone Research in Pædiatrics·Hanneke M van SantenW Hamish Wallace

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Current Treatment Options in Oncology
Katherine E Dillon, Clarisa R Gracia
Journal of Human Reproductive Sciences
Ariel Revel, Shoshana Revel-Vilk
© 2022 Meta ULC. All rights reserved