Fertility Preservation Outcomes in Adolescent and Young Adult Feminizing Transgender Patients

Pediatrics
Emily P BarnardHanna Valli-Pulaski

Abstract

Fertility preservation enables patients undergoing gonadotoxic therapies to retain the potential for biological children and now has broader implications in the care of transgender individuals. Multiple medical societies recommend counseling on fertility preservation before initiating therapy for gender dysphoria; however, outcome data pre- and posttreatment are limited in feminizing transgender adolescents and young adults. The University of Pittsburgh Institutional Research Board approved this study. Data were collected retrospectively on transgender patients seeking fertility preservation between 2015 and 2018, including age at initial consultation and semen analysis parameters. Eleven feminizing transgender patients accepted a referral for fertility preservation during this time; consultation occurred at median age 19 (range 16-24 years). Ten patients attempted and completed at least 1 semen collection. Eight patients cryopreserved semen before initiating treatment. Of those patients, all exhibited low morphology with otherwise normal median semen analysis parameters. In 1 patient who discontinued leuprolide acetate to attempt fertility preservation, transient azoospermia of 5 months' duration was demonstrated with subseque...Continue Reading

References

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Sep 26, 2017·The Journal of Clinical Endocrinology and Metabolism·Wylie C HembreeGuy G T'Sjoen
Oct 17, 2017·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·John F StrangVeronica Gomez-Lobo
Jan 1, 2016·Transgender Health·Emilie K Johnson, Courtney Finlayson
Mar 6, 2018·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Diane ChenBrian Mustanski
Oct 13, 2018·Urology·Amanda J AdeleyeJames F Smith
Oct 26, 2018·International Journal of Clinical Oncology·Koji Kawai, Hiroyuki Nishiyama

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Citations

Dec 13, 2019·Journal of Assisted Reproduction and Genetics·Sharrόn L ManuelMary Ellen Pavone
Jun 3, 2020·Culture, Health & Sexuality·Daphna Birenbaum-CarmeliPasquale Patrizio
Aug 17, 2020·The Journal of Clinical Endocrinology and Metabolism·Allison C Mayhew, Veronica Gomez-Lobo
May 11, 2021·Plastic and Reconstructive Surgery. Global Open·Oscar J ManriqueHoward N Langstein
Jun 20, 2021·Reproductive Biomedicine Online·Nathalie SermondadeCharlotte Dupont

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