Fertility preservation with ovarian stimulation and time to treatment in women with stage II-III breast cancer receiving neoadjuvant therapy

Breast Cancer Research and Treatment
A Jo ChienMitchell P Rosen

Abstract

To determine whether fertility preservation with ovarian stimulation (OS) results in treatment delay in breast cancer (BC) patients receiving neoadjuvant therapy (NAT). This is a retrospective study of women screened for the prospective neoadjuvant ISPY2 trial at the University of California San Francisco. All patients were <43, had stage II-III BC, and received neoadjuvant therapy. Time to initiation of NAT was compared between women who underwent OS (STIM) and women who did not (control). Patient and tumor characteristics, as well as oncologic outcomes, were compared between STIM and control groups. 82 patients were included (34 STIM and 48 control). STIM patients were overall younger (mean = 35 vs. 36.9 years old, p = 0.06), and more likely to be childless (79.4 vs 31.2%, p < 0.0001) than controls. Mean time from diagnosis to initiation of NAT was 40 days, with no significant difference between STIM and control groups (mean 39.8 days vs 40.9 days, p = 0.75). Mean time from diagnosis to fertility consultation was 16.3 days. With median follow-up of 79 months, 16 (19.5%) patients have recurred or died from BC. Rates of pCR, recurrence, and death were similar in both groups. Six of 34 STIM patients have undergone embryo transfe...Continue Reading

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Citations

Jan 30, 2018·Clinical and Experimental Reproductive Medicine·Hoon KimSeok Hyun Kim
Feb 14, 2019·Acta Obstetricia Et Gynecologica Scandinavica·Stine Gry KristensenClaus Yding Andersen
Jun 15, 2019·Science China. Life Sciences·Dongming LiuJie Qiao
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Apr 8, 2020·JCO Global Oncology·Avner HershlagSara L Bristow
Sep 23, 2018·Journal of Global Oncology·Avner HershlagSara L Bristow
Apr 3, 2020·Breast Cancer Research and Treatment·Ingeborg J H VriensVivianne C G Tjan-Heijnen
Jan 5, 2021·Breast Cancer Research and Treatment·Molly B MoravekMary Ellen Pavone
Dec 18, 2020·Critical Reviews in Oncology/hematology·Petra VukovićMatteo Lambertini
May 14, 2020·Breast Care·Carolin MüllerGeorg-Peter Breitbach

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