Fertility-sparing treatment in early endometrial cancer: current state and future strategies.

Obstetrics & Gynecology Science
Andreas ObermairMonika Janda

Abstract

Endometrial cancer (EC) is the fifth most common cancer in women worldwide. Global estimates show rising incidence rates in both developed and developing countries. Most women are diagnosed postmenopausal, but 14-25% of patients are premenopausal and 5% are under 40 years of age. Established risk factors include age and hyperestrogenic status associated with nulliparity, obesity, and metabolic syndrome. Standard treatment for EC, which involves total hysterectomy and bilateral salpingo-oophorectomy, has excellent survival outcomes, particularly for low-grade endometrioid tumors. However, it leads to permanent loss of fertility among women who wish to preserve their reproductive potential. With current trends of reproductive-age women delaying childbearing, rising EC incidence rates, and a growing epidemic of obesity, particularly in developed countries, research on conservative non-surgical treatment approaches remains a top priority. Fertility-sparing treatment predominantly involves the use of oral progestins and levonorgestrel-releasing intrauterine devices, which have been shown to be feasible and safe in women with early stage EC and minimal or no myometrial invasion. However, data on the efficacy and safety of conservativ...Continue Reading

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Citations

Nov 1, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Annabelle BrennanMartha Hickey
Apr 4, 2021·Journal of Clinical Medicine·Krzysztof GałczyńskiAndrzej Semczuk
May 4, 2021·International Journal of Surgical Pathology·Levon KatsakhyanKumarasen Cooper
Jul 23, 2021·Minimally Invasive Therapy & Allied Technologies : MITAT : Official Journal of the Society for Minimally Invasive Therapy·José Carugno, Adriana Wong

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Methods Mentioned

BETA
hysterectomy
biopsy

Clinical Trials Mentioned

NCT00788671
NCT01686126
NCT03538704
NCT03463252
NCT03241914
NCT01968317
NCT02990728
NCT01594879

Software Mentioned

feMMe

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