Fertility status of Hodgkin lymphoma patients treated with chemotherapy and adjuvant gonadotropin-releasing hormone analogues

Journal of Assisted Reproduction and Genetics
M HuserP Ventruba

Abstract

Aim of this prospective observational study was to analyze fertility status of Hodgkin lymphoma (HL) patients treated with different types of chemotherapy while receiving GnRH analogues to preserve ovarian function. Fertility status was assessed among 108 females in reproductive age treated by curative chemotherapy for freshly diagnosed HL between 2005 and 2010 in university-based tertiary fertility and oncology center. All patients received GnRH analogues during chemotherapy to preserve their ovarian function. Their reproductive functions were assessed by follicle-stimulating hormone (FSH) measurement and pregnancy achievement. Ovarian function was determined separately in three groups with increasing gonadotoxicity of chemotherapy. One year following the treatment, normal ovarian function was found in 89 (82.4%) of patients. Two years after chemotherapy, 98 (90.7%) of patients retained their ovarian function, and 23 (21.3%) achieved clinical pregnancy during the follow-up period. Average FSH after chemotherapy was 11.6 ± 17.9 IU/l 1 year after the treatment resp. 9.0 ± 13.8 at the 2 years interval. There were significantly more patients with chemotherapy induced diminished ovarian reserve (chDOR) among the group receiving esc...Continue Reading

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Citations

Jul 26, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Caroline E WeibullIngrid Glimelius
Aug 17, 2019·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M SalamaT K Woodruff
Dec 1, 2020·Revista brasileira de ginecologia e obstetrícia : revista da Federação Brasileira das Sociedades de Ginecologia e Obstetrícia·Gabriel Acácio de Moura, Paula Bruno Monteiro
Jan 29, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M SalamaT K Woodruff
Feb 15, 2019·Aktuelle Urologie·Pierre Einwaller

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