Fertilization and pregnancy after assisted oocyte activation and intracytoplasmic sperm injection in a case of round-headed sperm associated with deficient oocyte activation capacity

Fertility and Sterility
A V RybouchkinM Dhont

Abstract

To investigate a method of assisted activation of human oocytes for the treatment of infertility resulting from globozoospermia associated with deficient oocyte activation capacity. The mouse oocyte activation test was used to analyze the oocyte activation capacity of the sperm cells of a patient with globozoospermia. Fresh donor human oocytes were used for determining the most appropriate procedure for oocyte activation. Infertility Center, University Hospital of Ghent. A couple with infertility resulting from globozoospermia. Intracytoplasmic sperm injection, assisted oocyte activation, and embryo transfer. Oocyte activation and fertilization rates, implantation, and pregnancy. Deficiency in oocyte activation capacity was found in the sperm of a patient with globozoospermia. This deficiency was proven by the mouse oocyte activation test and was confirmed further by lack of activation of human oocytes after simple sperm injection. Only human oocytes that were injected with sperm and subjected to calcium chloride and ionophore treatment underwent activation. Transfer of embryos obtained by this procedure of assisted oocyte activation resulted in an ongoing pregnancy. Assisted oocyte activation of human oocytes is useful when gl...Continue Reading

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Citations

Oct 16, 2013·Reproductive Biomedicine Online·Frauke Vanden MeerschautPetra De Sutter
Jul 12, 2002·Molecular Reproduction and Development·Masumi HirabayashiShinichi Hochi
Mar 23, 2011·Journal of Assisted Reproduction and Genetics·Astrid StecherNicolas Herbert Zech
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Apr 19, 2015·Human Reproduction Update·Charles CouttonPierre F Ray
May 4, 2015·Reproductive Health·Bogdan DorofteiGeraldine Emerson

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