Ferulic Acid against Cyclophosphamide-Induced Heart Toxicity in Mice by Inhibiting NF-κB Pathway

Evidence-based Complementary and Alternative Medicine : ECAM
Yafan SongXiaobin Ma

Abstract

The purpose of the present study was to elucidate the protective effects of ferulic acid (FA) against cyclophosphamide- (CTX-) induced changes in mice. Forty-eight male ICR mice were divided into four groups. Control group was intraperitoneally (i.p.) injected with 200 μL of phosphate buffer saline (PBS). Model group was intraperitoneally injected with a single dose of CTX (200 mg/kg). FA (50 mg/kg) and FA (100 mg/kg) groups were intraperitoneally injected with a single dose of CTX (200 mg/kg) followed by the intragastric treatment with FA (50, 100 mg/kg) for 7 consecutive days. After 12 d, the mice were sacrificed to analyze the hematological, biochemical, histological parameters and mechanism research. The results indicated that FA significantly decreased the serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatine kinase (CK), lactate dehydrogenase (LDH), interleukin-6 (IL-6), IL-1β, and tumor necrosis factor-α (TNF-α) in CTX-injected mice. In addition, FA effectively reduced the total numbers of white blood cells (WBCs), red blood cells, platelets, and hemoglobin content. FA also obviously attenuated the histological changes of the heart tissues caused by CTX. Moreover, Western blot demonst...Continue Reading

References

Nov 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J D ShepherdG L Phillips
Oct 2, 1998·Cancer Immunology, Immunotherapy : CII·K K Bass, M J Mastrangelo
Mar 19, 2003·British Journal of Pharmacology·Adrienn KisGary F Baxter
May 27, 2004·Phytotherapy Research : PTR·M Sri BalasubashiniVenugopal P Menon
Sep 14, 2006·Journal of Agricultural and Food Chemistry·Pirjo MattilaRiitta Törrönen
Dec 6, 2006·Medicina clínica·Ignacio Gil-Ortega, Juan Carlos Kaski
Jan 20, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mohamed L SalemDavid J Cole
Jan 3, 2014·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Hasan Atilla OzkanZafer Gulbas
Jan 24, 2015·International Immunopharmacology·Tong ChenHui Ji
Apr 15, 2015·Toxicology and Applied Pharmacology·Daniel J ConklinAruni Bhatnagar

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Citations

Jun 2, 2016·International Journal of Molecular Sciences·Xiu-Ying ChenWei Zhang
May 27, 2020·Oxidative Medicine and Cellular Longevity·Muluken Altaye AyzaAbera Hadgu Berhe
Feb 7, 2021·Neurochemical Research·Surabhi ThapliyalRavi Gandham

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Methods Mentioned

BETA
ELISA
light microscopy
protein assay
electrophoresis

Software Mentioned

GraphPad

Related Concepts